About: Liposomal MUC1/PET-lipid A Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Liposomal MUC1/PET-lipid A Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • Liposomal MUC1/PET-lipid A Vaccine
NCI_META_CUI
  • CL435510
PDQ_Open_Trial_Search_ID
  • 729635
PDQ_Closed_Trial_Search_ID
  • 729635
FULL_SYN
  • Liposomal MUC1/PET-lipid A VaccinePTNCI
  • ONT-10CNNCI
DEFINITION
  • A cancer vaccine comprised of a 43 amino acid epitope from glycoprotein MUC1 (mucin 1) and the synthetic Toll-like receptor 4 (TLR-4) agonist PET lipid A encapsulated in cholesterol/dipalmitoylphosphatidylcholine (DPPC)/dimyristoylphosphatidylglycerol (DMPG) liposomes, with potential immunostimulatory and antineoplastic activities. The MUC1 epitope is composed of two 20 amino glycosylated VNTR (various number tandem repeats) from human MUC1A and including 6 glycosylated sites modified by Tn (alfa-N-acetyl-D-galactosamine). Immunization of liposomal MUC1/PET-lipid A vaccine results in an antibody as well as a cytotoxic T-lymphocyte (CTL) response against hypoglycosylated MUC1 expressing tumor cells. The tumor associated antigen MUC1, a type I transmembrane protein, is overexpressed and aberrantly glycosylated in a variety of tumor cells. As a vaccine adjuvant, PET lipid A, also known as penta erythritol lipid A, stimulates both cellular and humoral responses to the vaccine antigen.NCI
code
  • C101262
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