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AttributesValues
rdf:type
rdfs:label
  • Elsiglutide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Elsiglutide
NCI_META_CUI
  • CL433984
FDA_UNII_Code
  • SC864Q40VB
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 728622
PDQ_Closed_Trial_Search_ID
  • 728622
FULL_SYN
  • ElsiglutidePTNCI
  • ZP1846CNNCI
  • ELSIGLUTIDEPTFDASC864Q40VB
DEFINITION
  • A synthetic glucagon-like peptide-2 (GLP-2) analogue with potential antidiarrheal and intestinotrophic activities. Upon subcutaneous administration, elsiglutide, a 39 amino acid polypeptide, binds to GLP-2 receptors and thereby promotes proliferation of epithelial cells. Regeneration of endothelial cells damaged during chemotherapy may prevent or decrease chemotherapy-induced diarrhea. In addition, elsiglutide may prevent chemotherapy-induced intestinal injury. GLP-2, a peptide hormone primarily produced in the small intestines in response to food, plays a key role in intestinal epithelial growth, metabolism and regeneration of epithelial cells.NCI
code
  • C101131
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