About: Nafazatrom     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Nafazatrom
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Nafazatrom
UMLS_CUI
  • C0053025
CAS_Registry
  • 59040-30-1
FDA_UNII_Code
  • K94216221B
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39508
PDQ_Closed_Trial_Search_ID
  • 39508
Chemical_Formula
  • C16H16N2O2
Legacy_Concept_Name
  • Nafazatrom
FULL_SYN
  • 1-(2-(beta-naphthyloxy)ethyl)-3-methyl-2-pyrazolin-5-oneSNNCI
  • 3H-pyrazol-3-one,2,4-dihydro-5-methyl-2-(2-(2-naphthalenyloxy)ethylSNNCI
  • NAFAZATROMPTFDAK94216221B
  • Bay g 6575CNNCI
  • Bay-g 6575CNNCI
  • NafazatromPTNCI
DEFINITION
  • A pyrazolinone derivative with potential antimetastatic activities. Nafazatrom, originally developed as an antithrombotic agent, inhibits the key prostaglandin catabolic enzyme, 15-hydroxyprostaglandin dehydrogenase, which prolongs the biological half-life of prostacyclin (prostaglandin I2; PGI2) and prevents intravascular coagulation. This agent also serves as a reducing cofactor with the hydroperoxidase moiety of cyclooxygenase and accelerates the conversion of arachidonic acid into precursors of PGI2. An elevated level of PGI2 prevents aggregation of platelets; subsequently it decreases the formation of tumor cell-platelet aggregates as well as their sequestration in blood vessels, which is an important initiating step in the development of metastasis.NCI
code
  • C1010
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