About: Synthetic Breast Cancer Peptides-Tetanus Toxoid-Poly ICLC Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Synthetic Breast Cancer Peptides-Tetanus Toxoid-Poly ICLC Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Synthetic Breast Cancer Peptides-Tetanus Toxoid-Poly ICLC Vaccine
NCI_META_CUI
  • CL434402
PDQ_Open_Trial_Search_ID
  • 726670
PDQ_Closed_Trial_Search_ID
  • 726670
FULL_SYN
  • Synthetic Breast Cancer Peptides-Tetanus Toxoid-Poly ICLC VaccinePTNCI
DEFINITION
  • A cancer vaccine comprised of nine class I major histocompatibility complex (MHC)-restricted breast cancer associated peptides, the tetanus toxoid helper peptide and the Toll-like receptor 3 (TLR3) agonist poly ICLC, with potential immunostimulatory and antineoplastic activities. The nine peptides derived from six cancer associated proteins are epidermal growth factor receptor 2 (HER2/neu), carcinoembryonic antigen (CEA) and four cancer/testis antigens (CTAs: MAGE-A1, -A3, -A10, and NY-ESO-1). Vaccination with this vaccine may elicit a specific cytotoxic T-lymphocyte (CTL) response against cells overexpressing these tumor associated antigens (TAAs). As a nonspecific T-helper epitope, tetanus toxoid helper peptide binds to class II MHC and results in long-term immunopotentiation by increasing the helper T-cell response. Poly ICLC, the double-stranded RNA molecules of polyinosinic-polycytidylic acid stabilized with poly L-lysine in carboxymethylcellulose, binds to TLR3 and induces the release of cytokines which may help boost the immune response against the TAAs.NCI
code
  • C100099
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