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  • Farmakokinetické parametry paklitaxelu byly zjišťovány po 3hodinových a 24hodinových infuzích dávek 135 a 175 mg/m2. Poločas eliminace se pohybuje mezi 3,0 až 52,7 hodinami, hodnoty celkové clearance mezi 11,6 až 24,0 l/hod/m2. Celková clearance se při vyšších plasmatických hladinách paklitaxelu snižuje. (cs)
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