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  • Tabulka č. 6 Srovnání průměrných ±SD parametrů farmakokinetiky v různých stadiích postižení ledvin versus zdravé subjekty Parametr farmakokinetiky Zdravé subjekty Chronické onemocnění ledvin Stadium 3 Chronické onemocnění ledvin Stadium 4 Chronické onemocnění ledvin Stadium 5 HD PD n 25 15 14 14 8 Dávka (µg/kg) 0.240 0.047 0.036 0.240 0.240 CL/F (L/h) 3.6 ± 1.0 1.8 ± 0.5 1.5 ± 0.4 1.8 ± 0.8 1.8 ± 0.8 t½(h) 5.9 ± 2.8 16.8 ± 2.6 19.7 ± 7.2 13.9 ± 5.1 17.7 ± 9.6 fu* (%) 0.06 ± 0.01 0.06 ± 0.01 0.07 ± 0.02 0.09 ± 0.04 0.13 ± (cs)
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