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  • Nežádoucí účinky a onemocnění Exemestane (N = 2249) Tamoxifen (N = 2279) Návaly horka 491 (21.8%) 457 (20.1%) Únava 367 (16.3%) 344 (15.1%) Bolest hlavy 305 (13.6%) 255 (11.2%) Nespavost 290 (12.9%) 204 (9.0%) Zvýšené pocení 270 (12.0%) 242 (10.6%) Gynekologické 235 (10.5%) 340 (14.9%) Závratě 224 (10.0%) 200 (8.8%) Nevolnost 200 (8.9%) 208 (9.1%) Osteoporóza 116 (5.2%) 66 (2.9%) Vaginální krvácení 90 (4.0%) 121 (5.3%) Jiný primární karcinom 84 (3.6%) 125 (5.3%) Zvracení 50 (2.2%) 54 (2.4%) Poruchy zraku 45 (2.0%) 53 (2.3%) Trombembolie 16 (0.7%) 42 (1.8%) Osteoporotická zlomenina 14 (0.6%) 12 (0.5%) Infarkt myokardu 13 (0.6%) 4 (0.2%) Ve studii IES byla frekvence ischemických kardiálních událostí v léčebném rameni s exemestanem a tamoxifenem 4,5% versus 4,2%. (cs)
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