About: Dimetacrine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Dimetacrine (Istonil, Istonyl, Linostil, Miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (TCA) with imipramine-like effects used in Europe and formerly in Japan for the treatment of depression. (en)
http://linked.open...generalReferences
  • # Ishitani R, Saito E, Kitagawa H: The pharmacological studies on dimetacrine. I. Studies on the absorption, distribution and excretion of H3-labeled dimetacrine in the rat. Jpn J Pharmacol. 1970 Sep;20(3):432-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/5312397 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
  • withdrawn (en)
http://linked.open...drugbank/halfLife
  • Approximately 10 hours. (PMID 5312397) (en)
sameAs
Title
  • Dimetacrine (en)
adms:identifier
http://linked.open...y/drugbank/patent
http://linked.open...outeOfElimination
  • Approximately 70% of the doses were excreted in urine and feces within 2 days after treatment. (PMID 5312397) (en)
http://linked.open.../drugbank/synonym
  • Dimetacrine (en)
  • Istonil (en)
  • Istonyl (en)
  • Linostil (en)
  • Miroistonil (en)
  • 3-(9,9-dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine (en)
http://linked.open...drugbank/toxicity
  • Dimetacrine may induce severe cardiac toxicity in overdose. This property is unique among the tricyclic antidepressants. (en)
http://linked.open...umeOfDistribution
  • The highest concentrations of dimetacrine were found at 1 hour after administration but at 3 hours in brain, heart, lung, liver, spleen, kidney, skeletal muscle and adipose tissue of testes. (Carried out in mice, PMID 5312397). (en)
http://linked.open...ogy/drugbank/salt
  • (en)
http://linked.open...ynthesisReference
  • # http://worldwide.espacenet.com/publicationDetails/biblio?CC=GB&NR=933875&KC=&FT=E&locale=en_EP (en)
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 4757-55-5 (en)
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...-strongest-basic-
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