About: LULICONAZOLE     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Luliconazole was approved by the FDA (USA) in November 2013 and is marketed under the brand name Luzu. It is a topical antifungal agent that acts by unknown mechanisms but is postulated to involve altering the synthesis of fungi cell membranes. Luliconazole is also approved in Japan. (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # Niwano Y, Kuzuhara N, Kodama H, Yoshida M, Miyazaki T, Yamaguchi H: In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent. Antimicrob Agents Chemother. 1998 Apr;42(4):967-70. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9559824 # Uchida K, Nishiyama Y, Yamaguchi H: In vitro antifungal activity of luliconazole (NND-502), a novel imidazole antifungal agent. J Infect Chemother. 2004 Aug;10(4):216-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15365862 # Lexicomp. # FDA label. (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • The half life of luliconazole has yet to be determined. (en)
http://linked.open...ugbank/indication
  • Luliconazole is indicated in adults aged 18 years and older for the topical treatment of fungal infections caused by Trichophyton rubrum and Epidermophyton floccosum, specifically tinea pedis, cruris, and corporis. (en)
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Title
  • LULICONAZOLE (en)
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http://linked.open...mechanismOfAction
  • The exact mechanism of action for luliconazole's anti-fungal activity is still not known, but luliconazole is thought to inhibit the enzyme lanosterol demethylase. Lanosterol demethylase is needed for the synthesis of ergosterol, which is a major component of the fungus cell membranes. (en)
http://linked.open...outeOfElimination
  • The route of elimination of luliconazole has yet to be determined. (en)
http://linked.open.../drugbank/synonym
  • NND-502 (en)
http://linked.open...drugbank/toxicity
  • In clinical trials, no serious toxicity was reported, only local irritation (mild contact dermatitis and cellulitis) at the site of application was found. (en)
http://linked.open...umeOfDistribution
  • The volume of distribution was not quantified. (en)
http://linked.open...nk/proteinBinding
  • Plasma protein binding of luliconazole is >99%. (en)
http://linked.open...ynthesisReference
  • Niwano Y, Kuzuhara N, Kodama H, Yoshida M, Miyazaki T, Yamaguchi H: In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent. Antimicrob Agents Chemother. 1998 Apr;42(4):967-70. (en)
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http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
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http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
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http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • Although luliconazole is administered topically, clinical studies have shown that after the first dose in patients with tina pedis, a maximum plasma concentration of 0.40 ± 0.76 ng/mL (mean ± SD) occurred in 16.9 ± 9.39 hours (mean ± SD). (en)
http://linked.open.../affectedOrganism
  • Fungi (en)
http://linked.open...casRegistryNumber
  • 187164-19-8 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...rugbank/clearance
  • The clearance of luliconazole has yet to be determined. (en)
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...-strongest-basic-
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