About: Gadoxetate

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Gadoxetate is a paramagnetic gadolinium-containing contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up the drug. It is marketed by Bayer HealthCare Pharmaceuticals and FDA approved on July 3, 2008. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5A97-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# FDA label # Van Beers BE, Pastor CM, Hussain HK: Primovist, Eovist: what to expect? J Hepatol. 2012 Aug;57(2):421-9. doi: 10.1016/j.jhep.2012.01.031. Epub 2012 Apr 12. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/22504332 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	Terminal elimination half-life, healthy subjects, adults = 0.91 - 0.95 hours (en)
http://linked.open...ugbank/indication	Gadoxetate is used as a contrast medium for magnetic resonance imaging (MRI) to detect and characterize lesions in the liver. (en)
sameAs	Gadoxetate
Title	Gadoxetate (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB08884/identifier/drugbank/DB08884 http://linked.opendata.cz/resource/drugbank/drug/DB08884/identifier/kegg-drug/D04288 http://linked.opendata.cz/resource/drugbank/drug/DB08884/identifier/national-drug-code-directory/50419-320-05 http://linked.opendata.cz/resource/drugbank/drug/DB08884/identifier/pharmgkb/PA165985534 http://linked.opendata.cz/resource/drugbank/drug/DB08884/identifier/wikipedia/Gadoxetic_acid
http://linked.open...mechanismOfAction	When gadoxetate disodium is placed in an external magnetic field, a large magnetic moment is produced. As a result, a magnetic field is induced around the tissue. The water protons in the vicinity are disrupted such that the change the proton density and spin characteristics are detected and visualized by a device. (en)
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/5798092 http://linked.opendata.cz/resource/drugbank/patent/6039931
http://linked.open...outeOfElimination	Gadoxetate disodium is eliminated equally via urine and feces. Multidrug resistance protein 2 actively transports/excretes gadoxetate disodium into the bile. (en)
http://linked.open.../drugbank/synonym	Gd-EOB-DTPA (en) SHL-569B (en)
http://linked.open...drugbank/toxicity	LD50, oral, rat = 18100 mg/kg; LD50, oral, mouse = 14500 mg/kg; LD50, IV, rat = 3600 - 7300 mg/kg; LD50, IV, mouse = 5400 - 10900 mg/kg; LD50, IV, dog = >2200 mg/kg (en)
http://linked.open...umeOfDistribution	Total volume of distribution at steady state is 0.21 L/kg. Gadoxetate disodium cannot diffuse through the blood brain barrier. The two transporters that gadoxetate disodium can enter the hepatocyte through are OATP1B1 and OATP1B3. Gadoxetate disodium may also exit the heptaocyte and go back into sinusoidal space via active transport through multidrug resistance protein 3 and 4. (en)
http://linked.open...nk/proteinBinding	<10% protein bound. Because it is more protein bound than other gadolinium-based contrast agents, gadoxetate disodium has increased T1 relaxivity. This results in an enhancement of the signal. (en)
http://linked.open...ogy/drugbank/salt	(en)
foaf:page	http://www.drugs.com/mtm/gadoxetate.html http://www.rxlist.com/eovist-drug.htm
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	135326-22-6 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	Clearance may be lower in older patients. Total serum clearance (CLtot) = 250 mL/min; Renal clearance (CLr) = 120 mL/min (en)
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