About: Taliglucerase Alfa

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Taliglucerase alfa is the recombinant active form of the human lysosomal enzyme, β-glucocerebrosidase. It was approved in 2012 and is marketed under the name Elelyso for use in patients with type 1 Gaucher's disease. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B59FE-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59FF-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Zimran A, Brill-Almon E, Chertkoff R, Petakov M, Blanco-Favela F, Munoz ET, Solorio-Meza SE, Amato D, Duran G, Giona F, Heitner R, Rosenbaum H, Giraldo P, Mehta A, Park G, Phillips M, Elstein D, Altarescu G, Szleifer M, Hashmueli S, Aviezer D: Pivotal trial with plant cell-expressed recombinant glucocerebrosidase, taliglucerase alfa, a novel enzyme replacement therapy for Gaucher disease. Blood. 2011 Nov 24;118(22):5767-73. doi: 10.1182/blood-2011-07-366955. Epub 2011 Sep 6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/21900191 # Aviezer D, Brill-Almon E, Shaaltiel Y, Hashmueli S, Bartfeld D, Mizrachi S, Liberman Y, Freeman A, Zimran A, Galun E: A plant-derived recombinant human glucocerebrosidase enzyme--a preclinical and phase I investigation. PLoS One. 2009;4(3):e4792. doi: 10.1371/journal.pone.0004792. Epub 2009 Mar 11. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/19277123 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	The half life is between 18.9 to 28.7 min. (en)
http://linked.open...ugbank/indication	For the treatment of adult Type 1 Gaucher disease. (en)
sameAs	Taliglucerase Alfa
Title	Taliglucerase Alfa (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB08876/identifier/drugbank/DB08876 http://linked.opendata.cz/resource/drugbank/drug/DB08876/identifier/kegg-drug/D09675 http://linked.opendata.cz/resource/drugbank/drug/DB08876/identifier/wikipedia/Taliglucerase_alfa
http://linked.open...mechanismOfAction	Taliglucerase alfa is different from human glucocerebrosidase by two amino acids at the N terminal and up to 7 amino acids at the C terminal. This recombinant enzyme allows the hydrolysis reaction of glucocerebroside to glucose and ceramide that naturally occurs in healthy individuals. (en)
http://linked.open...outeOfElimination	Route of elimination was not determined. (en)
http://linked.open.../drugbank/synonym	prGCD (en)
http://linked.open...drugbank/toxicity	The most common toxic reaction seen was infusion reactions such as urticaria, arthralgia, headache, and chest pain due to IV administration. (en)
http://linked.open...umeOfDistribution	The steady state volume of distribution is between 7.30 to 11.7 L. (en)
http://linked.open...k/foodInteraction	No food effects found. (en)
http://linked.open...nk/proteinBinding	Plasma protein binding was not quantified. (en)
http://linked.open...ynthesisReference	Shaaltiel Y, Bartfeld D, Hashmueli S, Baum G, Brill-Almon E, Galili G, Dym O, Boldin-Adamsky SA, Silman I, Sussman JL, Futerman AH, Aviezer D: Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system. Plant Biotechnol J. 2007 Sep;5(5):579-90. Epub 2007 May 24. (en)
foaf:page	http://www.drugs.com/mtm/taliglucerase-alfa.html http://www.rxlist.com/elelyso-drug.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B5A02-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5A01-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B5A00-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Taliglucerase alfa
http://linked.open...ugbank/absorption	Taliglucerase alfa is administered IV so absorption is 100%. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	37228-64-1 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	The systemic clearance was approximately 30 L/hr and 20 L/hr for 30 and 60 units/kg, respectively. (en)

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