About: Fidaxomicin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	One of the first narrow spectrum macrocyclic antibiotic, it is a natural compound and is structurally similar to compounds in lipiarmycin-a fermentation mixture. FDA approved on May 27, 2011. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B59DF-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59E0-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Artsimovitch I, Seddon J, Sears P: Fidaxomicin is an inhibitor of the initiation of bacterial RNA synthesis. Clin Infect Dis. 2012 Aug;55 Suppl 2:S127-31. doi: 10.1093/cid/cis358. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/22752861 # Crawford T, Huesgen E, Danziger L: Fidaxomicin: a novel macrocyclic antibiotic for the treatment of Clostridium difficile infection. Am J Health Syst Pharm. 2012 Jun 1;69(11):933-43. doi: 10.2146/ajhp110371. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/22610025 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	200 mg, healthy subjects = 11.7 hours (en)
http://linked.open...ugbank/indication	Treatment of Clostridium difficile-associated diarrhea (en)
sameAs	Fidaxomicin
Title	Fidaxomicin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB08874/identifier/chebi/68590 http://linked.opendata.cz/resource/drugbank/drug/DB08874/identifier/drugbank/DB08874 http://linked.opendata.cz/resource/drugbank/drug/DB08874/identifier/kegg-drug/D09394 http://linked.opendata.cz/resource/drugbank/drug/DB08874/identifier/national-drug-code-directory/52015-080-01 http://linked.opendata.cz/resource/drugbank/drug/DB08874/identifier/wikipedia/Fidaxomicin
http://linked.open...mechanismOfAction	Fidaxomicin is a bactericidal-type antibiotic that inhibits RNA polymerase sigma subunit. RNA polymerase is responsible for transcription in the bacteria therefore fidaxomicin will inhibit protein synthesis. As a result, apoptosis is triggered in susceptible organisms such as C. difficile. (en)
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/7378508 http://linked.opendata.cz/resource/drugbank/patent/7863249 http://linked.opendata.cz/resource/drugbank/patent/7906489
http://linked.open...outeOfElimination	Feces (>92% as unchanged drugs and metabolites) and urine (<1% of drug was excreted) (en)
http://linked.open.../drugbank/synonym	Dificid (en) Difimicin (en) Lipiarmicin (en) Lipiarmycin (en) Lipiarrmycin (en) OPT 80 (en) OPT-80 (en) PAR 101 (en) PAR-101 (en) Tiacumicin B (en)
http://linked.open...umeOfDistribution	Fidaxomicin is largely confined in the gastrointestinal tract and is not distributed extensively in the systemic. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/8-12-12-92
http://linked.open...k/foodInteraction	Food decreases Cmax of fidaxomicin and its metabolites however this is not considered clinically significant. (en)
http://linked.open...ynthesisReference	Youe-Kong Shue, Chi-Jen Frank Du, Ming-Hsi Chiou, Mei-Chiao Wu, Yuan-Ting Chen, Franklin W. Okumu, Jonathan James Duffield, "Medium for the Production of Tiacumicin B." U.S. Patent US20100028970, issued February 04, 2010. (en)
foaf:page	http://www.drugs.com/ppa/fidaxomicin.html http://www.rxlist.com/dificid-drug.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B59E5-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B59EB-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B59EA-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B59E7-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B59E8-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B59E9-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B59E3-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B59E1-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B59E4-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B59E2-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Fidaxomicin
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B59F1-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B59F2-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B59EC-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B59ED-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B59EF-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B59EE-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B59F0-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Fidaxomicin is not systemically absorbed as shown by a plasma concentrations below the lower limit of quantification after single-dose or multiple-dose. In contrast, fecal concentrations of fidaxomicin are much higher and are concentration-dependent. Cmax = 2 hours; Tmax = 5.2 ng/mL; AUC = 14 ng•hr/mL (en)
http://linked.open.../affectedOrganism	Gram-positive Bacteria (en) Peptoclostridium difficile (en)
http://linked.open...casRegistryNumber	873857-62-6 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B59F7-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B59F9-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B59FA-363D-11E5-9242-09173F13E4C5
http://linked.open...k/Number-of-Rings	http://linked.opendata.cz/resource/drugbank/property/271B59F6-363D-11E5-9242-09173F13E4C5
http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B59F5-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B59F8-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B59E6-363D-11E5-9242-09173F13E4C5
http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B59F3-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B59F4-363D-11E5-9242-09173F13E4C5

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