About: Tafluprost     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • A prostaglandin analogue ester prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. Chemically, tafluprost is a fluorinated analog of prostaglandin F2-alpha. Tafluprost was approved for use in the U.S. on February 10, 2012. (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # Papadia M, Bagnis A, Scotto R, Traverso CE: Tafluprost for glaucoma. Expert Opin Pharmacother. 2011 Oct;12(15):2393-401. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/21916788 # Pantcheva MB, Seibold LK, Awadallah NS, Kahook MY: Tafluprost: a novel prostaglandin analog for treatment of glaucoma. Adv Ther. 2011 Sep;28(9):707-15. Epub 2011 Aug 18. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/21858491 # Takagi Y, Nakajima T, Shimazaki A, Kageyama M, Matsugi T, Matsumura Y, Gabelt BT, Kaufman PL, Hara H: Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. Exp Eye Res. 2004 Apr;78(4):767-76. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15037111 # Fukano Y, Kawazu K: Disposition and metabolism of a novel prostanoid antiglaucoma medication, tafluprost, following ocular administration to rats. Drug Metab Dispos. 2009 Aug;37(8):1622-34. doi: 10.1124/dmd.108.024885. Epub 2009 May 28. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/19477946 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...ugbank/indication
  • Tafluprost is indicated for reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. (en)
sameAs
Title
  • Tafluprost (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Tafluprost acid is a prostanoid selective FP receptor agonist that is believed to reduce the intraocular pressure (IOP) by increasing the outflow of aqueous humor. Studies in animals and humans suggest that the main mechanism of action is increased uveoscleral outflow. (en)
http://linked.open...y/drugbank/patent
http://linked.open...outeOfElimination
  • Mean plasma tafluprost acid concentrations were below the limit of quantification of the bioanalytical assay (10 pg/mL) at 30 minutes following topical ocular administration of tafluprost 0.0015% ophthalmic solution. In male rats, it was observed that tafluprost was excreted into the feces. (en)
http://linked.open.../drugbank/synonym
  • Zioptan (en)
  • AFP-168 (en)
http://linked.open...drugbank/toxicity
  • Most common ocular adverse reaction is conjunctival hyperemia (range 4% – 20%). (en)
http://linked.open...umeOfDistribution
  • The highest concentration of tafluprost acid was found in the cornea and conjunctiva. (en)
http://linked.open.../drug/hasAHFSCode
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foaf:page
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http://linked.open...ugbank/absorption
  • Following instillation, tafluprost is absorbed through the cornea and is hydrolyzed to the biologically active acid metabolite, tafluprost acid. Tafluprost is an ester which makes the drug lipophillic enough to be quickly absorbed through. When administered to the eye, the peak plasma concentration (Cmax) and time to peak plasma concentration (Tmax) of tafluprost acid in healthy subjects was 26 pg/mL and 10 minutes respectively. a AUC, tafluprost acid = 394 pg*min/mL - 432 pg*min/mL. (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 209860-87-7 (en)
http://linked.open...drugbank/category
  • (en)
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