About: Dichloroacetic Acid     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Dichloroacetic acid, often abbreviated DCA, is an acid analogue of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms. The salts and esters of dichloroacetic acid are called dichloroacetates. Salts of DCA are used as drugs since they inhibit the enzyme pyruvate dehydrogenase kinase. Early reports of its activity against brain cancer cells led patients to treat themselves with DCA, which is commercially available in non-pharmaceutical grade. A phase 1 study in 5 patients concluded that DCA was safe, but wasn't designed to establish effectiveness. (en)
http://linked.open...gy/drugbank/group
  • experimental (en)
sameAs
Title
  • Dichloroacetic Acid (en)
adms:identifier
http://linked.open.../drugbank/synonym
  • DCA (en)
  • dichloroacetate (en)
http://linked.open...drugbank/toxicity
  • ORAL (LD50): Acute: 2820 mg/kg [Rat]; DERMAL (LD50): Acute: 510 mg/kg [Rabbit] (en)
http://linked.open...ynthesisReference
  • Joanne D. Burger, William L. Howard, "Method for preparing pentachloroacetone and dichloroacetic acid from isopropyl ethers." U.S. Patent US3996272, issued August, 1968. (en)
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  • 79-43-6 (en)
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