About: Mafenide     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Mafenide is a sulfonamide-type medication used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns. (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # Maghsoudi H, Salehi F, Khosrowshahi MK, Baghaei M, Nasirzadeh M, Shams R: Comparison between topical honey and mafenide acetate in treatment of burn wounds. Ann Burns Fire Disasters. 2011 Sep 30;24(3):132-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/22396671 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...ugbank/indication
  • Mafenide is indicated in the treatment of severe burns. (en)
sameAs
Title
  • Mafenide (en)
adms:identifier
http://linked.open...mechanismOfAction
  • The precise mechanism of mafenide is unknown. However, mafenide reduces the bacterial population in the avascular burn tissue and promotes spontaneous heeling of deep burns. (en)
http://linked.open...outeOfElimination
  • Renal—Metabolite rapidly excreted in urine in high concentrations; however, the parent compound has not been detected in urine. (en)
http://linked.open.../drugbank/synonym
  • Bensulfamide (en)
  • 4-(aminomethyl)benzenesulfonamide (en)
  • 4-Homosufanilamide (en)
  • Maphenidum (en)
http://linked.open...drugbank/toxicity
  • Since mafenide is metabolized to a carbonic anhydrase inhibitor, metabolic acidosis could occur. Mafenide is contraindicated in persons with renal impairment or sulfonamide hypersensitivity. (en)
http://linked.open.../drugbank/mixture
http://linked.open...ogy/drugbank/salt
  • (en)
http://linked.open...ynthesisReference
  • U.S. Patent 2,288,531. (en)
foaf:page
http://linked.open...ugbank/IUPAC-Name
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http://linked.open...ugbank/absorption
  • Mafenide is absorbed through devascularized areas into the systemic circulation following topical administration. (en)
http://linked.open.../affectedOrganism
  • Bacteria (en)
  • Gram negative and gram positive bacteria (en)
  • Pseudomonas aeruginosa (en)
http://linked.open...casRegistryNumber
  • 138-39-6 (en)
http://linked.open...k/Bioavailability
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http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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