About: Difluprednate

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Difluprednate is a topical corticosteroid indicated for the treatment of infammation and pain associated with ocular surgery. It is a butyrate ester of 6(α), 9(α)-difluoro prednisolone acetate. Difluprednate is abbreviated DFBA, or difluoroprednisolone butyrate acetate. It is indicated for treatment of endogenous anterior uveiti. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B543E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B543F-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Korenfeld MS, Silverstein SM, Cooke DL, Vogel R, Crockett RS: Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain. J Cataract Refract Surg. 2009 Jan;35(1):26-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/19101421 # Jamal KN, Callanan DG: The role of difluprednate ophthalmic emulsion in clinical practice. Clin Ophthalmol. 2009;3:381-90. Epub 2009 Jun 29. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/19668594 # https://online.epocrates.com/u/10a4844/Durezol # Morton KD, Van de Kar LD, Brownfield MS, Bethea CL: Neuronal cell bodies in the hypothalamic paraventricular nucleus mediate stress-induced renin and corticosterone secretion. Neuroendocrinology. 1989 Jul;50(1):73-80. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2666872 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For the treatment of inflammation and pain associated with ocular surgery. (en)
sameAs	Difluprednate Difluprednate
Title	Difluprednate (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB06781/identifier/chemspider/391990 http://linked.opendata.cz/resource/drugbank/drug/DB06781/identifier/drugbank/DB06781 http://linked.opendata.cz/resource/drugbank/drug/DB06781/identifier/pubchem-compound/443936 http://linked.opendata.cz/resource/drugbank/drug/DB06781/identifier/pubchem-substance/99443292 http://linked.opendata.cz/resource/drugbank/drug/DB06781/identifier/kegg-drug/D01266 http://linked.opendata.cz/resource/drugbank/drug/DB06781/identifier/pharmgkb/PA165958405 http://linked.opendata.cz/resource/drugbank/drug/DB06781/identifier/wikipedia/Difluprednate
http://linked.open...mechanismOfAction	Corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins (lipocortins). It is postulated that these proteins control the biosynthesis of potent mediators of infammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. (en)
http://linked.open...outeOfElimination	78.5% of radioactivity was excreted aftert 24 hours, and 99.5% by 7 days after a single dose of labeled difluprednate instilled in the right eyes of pigmented rabbits. (en)
http://linked.open.../drugbank/synonym	Durezol (en) DFBA (en) Difluoroprednisolone butyrate acetate (en)
http://linked.open...drugbank/toxicity	Preclinical pharmacokinetic and toxicity studies have established that difluprednate ophthalmic emulsion 0.05% given 4 times a day is not toxic to the eye. (en)
http://linked.open...ynthesisReference	Ercoli, A. and Gardi, R.; U.S. Patent 3,780,177; December 18,1973; assigned to Warner-Lambert Co. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0065341
foaf:page	http://www.drugs.com/durezol.html http://www.pdrhealth.com/drugs/rx/rx-mono.aspx?contentFileName=dur1999.html&contentName=Durezol&contentId=269 http://www.rxlist.com/durezol-drug.htm
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http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B5449-363D-11E5-9242-09173F13E4C5
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http://linked.open...l/drug/hasATCCode	Difluprednate
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http://linked.open...ugbank/absorption	Difluprednate penetrates the corneal epithelium rapidly and effectively. Low systemic absorption. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	23674-86-4 (en)
http://linked.open...drugbank/category	(en)
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