About: Amisulpride

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Amisulpride (trade name Solian) is an antipsychotic drug sold by Sanofi-Aventis. It is not approved for use in the United States, but is approved for use in Europe and Australia for the treatment of psychoses and schizophrenia. Additionally, it is approved in Italy for the treatment of dysthymia (under the brand name Deniban). Amisulpride is a selective dopamine antagonist. (en)
http://linked.open...generalReferences	# Rosenzweig P, Canal M, Patat A, Bergougnan L, Zieleniuk I, Bianchetti G: A review of the pharmacokinetics, tolerability and pharmacodynamics of amisulpride in healthy volunteers. Hum Psychopharmacol. 2002 Jan;17(1):1-13. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12404702 # Moller HJ: Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Oct;27(7):1101-11. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14642970 # Weizman T, Pick CG, Backer MM, Rigai T, Bloch M, Schreiber S: The antinociceptive effect of amisulpride in mice is mediated through opioid mechanisms. Eur J Pharmacol. 2003 Oct 8;478(2-3):155-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14575800 # Leucht S, Pitschel-Walz G, Engel RR, Kissling W: Amisulpride, an unusual "atypical" antipsychotic: a meta-analysis of randomized controlled trials. Am J Psychiatry. 2002 Feb;159(2):180-90. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11823257 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	Approximately 12 hours (en)
http://linked.open...ugbank/indication	Investigated for use/treatment in schizophrenia and schizoaffective disorders, mania in bipolar disorder, and depression. (en)
sameAs	Amisulpride Amisulpride
Title	Amisulpride (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB06288/identifier/chemspider/2074 http://linked.opendata.cz/resource/drugbank/drug/DB06288/identifier/drugbank/DB06288 http://linked.opendata.cz/resource/drugbank/drug/DB06288/identifier/guide-to-pharmacology/963 http://linked.opendata.cz/resource/drugbank/drug/DB06288/identifier/iuphar/963 http://linked.opendata.cz/resource/drugbank/drug/DB06288/identifier/pubchem-compound/2159 http://linked.opendata.cz/resource/drugbank/drug/DB06288/identifier/pubchem-substance/99443244 http://linked.opendata.cz/resource/drugbank/drug/DB06288/identifier/pharmgkb/PA162565877 http://linked.opendata.cz/resource/drugbank/drug/DB06288/identifier/wikipedia/Amisulpride
http://linked.open...mechanismOfAction	Amisulpride binds selectively to dopamine D(2) and D(3) receptors in the limbic system. Low doses of amisulpride preferentially block presynaptic D(2)/D(3)-dopamine autoreceptors, thereby enhancing dopaminergic transmission, whereas higher doses block postsynaptic receptors, thus inhibiting dopaminergic hyperactivity. It may also have 5-ht7 antagonistic effect, useful in depression treatment. (en)
http://linked.open.../drugbank/synonym	Aminosultopride (en) Amisulprida (en) Amisulpridum (en) 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-O-anisamide (en) 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide (en)
http://linked.open...drugbank/toxicity	Overdoses of amisulpride have been linked with torsades de pointes. (en)
http://linked.open...nk/proteinBinding	Low (17%) (en)
http://linked.open...ynthesisReference	"DrugSyn.org":http://www.drugsyn.org/Amisulpride.htm (en)
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http://linked.open...ugbank/absorption	Bioavailability is 48% following oral administration. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	53583-79-2 (en)
http://linked.open...drugbank/category	(en)
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