About: Teicoplanin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Teicoplanin is a glycopeptide antibiotic. It is a mixture of several compounds, five major (named teicoplanin A2-1 through A2-5) and four minor (named teicoplanin RS-1 through RS-4). All teicoplanins share a same glycopeptide core, termed teicoplanin A3-1, a fused ring structure to which two carbohydrates (mannose and N-acetylglucosamine) are attached. The major and minor components also contain a third carbohydrate moiety, β-D-glucosamine, and differ only by the length and conformation of a side chain attached to it. [Wikipedia] (en)
http://linked.open...generalReferences	# de Lalla F, Nicolin R, Rinaldi E, Scarpellini P, Rigoli R, Manfrin V, Tramarin A: Prospective study of oral teicoplanin versus oral vancomycin for therapy of pseudomembranous colitis and Clostridium difficile-associated diarrhea. Antimicrob Agents Chemother. 1992 Oct;36(10):2192-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1444298 # Bernareggi A, Borghi A, Borgonovi M, Cavenaghi L, Ferrari P, Vekey K, Zanol M, Zerilli LF: Teicoplanin metabolism in humans. Antimicrob Agents Chemother. 1992 Aug;36(8):1744-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1416858 # Yano R, Nakamura T, Tsukamoto H, Igarashi T, Goto N, Wakiya Y, Masada M: Variability in teicoplanin protein binding and its prediction using serum albumin concentrations. Ther Drug Monit. 2007 Aug;29(4):399-403. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17667792 # Pryka RD, Rodvold KA, Rotschafer JC: Teicoplanin: an investigational glycopeptide antibiotic. Clin Pharm. 1988 Sep;7(9):647-58. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2977108 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	70-100 hours (en)
http://linked.open...ugbank/indication	For the treatment of bacterial infections caused by susceptible microorganisms. (en)
sameAs	Teicoplanin Teicoplanin
Title	Teicoplanin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB06149/identifier/drugbank/DB06149 http://linked.opendata.cz/resource/drugbank/drug/DB06149/identifier/kegg-compound/C15820 http://linked.opendata.cz/resource/drugbank/drug/DB06149/identifier/kegg-drug/D02142 http://linked.opendata.cz/resource/drugbank/drug/DB06149/identifier/pharmgkb/PA164746244 http://linked.opendata.cz/resource/drugbank/drug/DB06149/identifier/wikipedia/Teicoplanin
http://linked.open...mechanismOfAction	Teicoplanin inhibits peptidoglycan polymerization, resulting in inhibition of bacterial cell wall synthesis and cell death. (en)
http://linked.open.../drugbank/synonym	Teichomycin (en) TEIC (en) Teichomycin a2 factor 2 (en)
http://linked.open...nk/proteinBinding	90% to 95% (en)
http://linked.open...ynthesisReference	Emil Toma, Madeleine Ravaoarinoro, "Production and characteristics of anti-teicoplanin polyclonal antibody." U.S. Patent US5612459, issued November, 1990. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0026325
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B491A-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4919-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Teicoplanin
http://linked.open...ugbank/absorption	Teicoplanin is poorly absorbed after oral administration but is 90% bioavailable when administered intramuscularly. (en)
http://linked.open.../affectedOrganism	Gram-positive Bacteria (en)
http://linked.open...casRegistryNumber	61036-62-2 (en)
http://linked.open...drugbank/category	(en)

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