About: CTI-01

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	CTI-01 (ethyl pyruvate) is a novel anti-inflammatory agent for the treatment of critical inflammatory conditions. CTI-01 shows a potent anti-inflammatory and tissue protection activity in multiple animal models of disease including pancreatitis, ischemia-reperfusion injury, sepsis, renal injury and endotoxemia. (en)
http://linked.open...generalReferences	# Kou QY, Guan XD: [Effect of ethyl pyruvate on indices of tissue oxygenation and perfusion in dogs with septic shock] Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008 Jan;20(1):34-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18199399 # Cheng BQ, Liu CT, Li WJ, Fan W, Zhong N, Zhang Y, Jia XQ, Zhang SZ: Ethyl pyruvate improves survival and ameliorates distant organ injury in rats with severe acute pancreatitis. Pancreas. 2007 Oct;35(3):256-61. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17895847 (en)
http://linked.open...gy/drugbank/group	investigational (en)
http://linked.open...ugbank/indication	Investigated for use/treatment in burns and burn infections, cardiac surgery, inflammatory disorders (unspecified), ischemic reperfusion injury, and sepsis and septicemia. (en)
sameAs	CTI-01
Title	CTI-01 (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB05869/identifier/chemspider/11544 http://linked.opendata.cz/resource/drugbank/drug/DB05869/identifier/drugbank/DB05869 http://linked.opendata.cz/resource/drugbank/drug/DB05869/identifier/pubchem-compound/12041
http://linked.open...mechanismOfAction	CTI-01 inhibits the systemic release of cytokines, such as TNF-alpha and HMGB1, which promote the body's inflammatory response. The over-expression of these cytokines has been linked to diseases that occur in critical care settings, such as severe organ damage following cardiopulmonary bypass (CPB) and post-operative ileus following abdominal surgery. (en)
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http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B483F-363D-11E5-9242-09173F13E4C5

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