| Attributes | Values |
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| rdf:type
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| http://linked.open...gbank/description
| - Preotact is a pharmaceutical form of parathyroid hormone (PTH). PTH is a single-chain polypeptide composed of 84 amino acids. Preotact contains recombinant human parathyroid hormone which is identical to the full-length native 84-amino acid polypeptide. It is produced as a fusion protein. Post-translational processing involves the cleavage of the OmpA leader sequence, leaving the mature protein as a single-chain 84 amino-acids polypeptide (9.4 kDa) whose sequence is identical to that of the full-length native endogenous human PTH. It has no disulfide bonds and no glycosylation sites. Preotact is used in the treatment of osteoporosis in postmenopausal women at high risk of osteoporotic fractures. Preotact is marketed in Europe by Nycomed. Preos is a registered trade mark owned by NPS Pharmaceuticals, Inc. The name Preos and the New Drug Application is pending approval by the U.S. Food and Drug Administration (FDA). (en)
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| http://linked.open...y/drugbank/dosage
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| http://linked.open...generalReferences
| - # Sosa Henriquez M, Diez Perez A: [Parathyroid hormone in the treatment of osteoporosis] An Med Interna. 2007 Feb;24(2):87-97. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17590097 (en)
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| http://linked.open...gy/drugbank/group
| - approved (en)
- investigational (en)
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| http://linked.open...drugbank/halfLife
| - The mean half-life is approximately 1.5 hours. (en)
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| http://linked.open...ugbank/indication
| - For use/treatment in osteoporosis. (en)
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| sameAs
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| Title
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| adms:identifier
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| http://linked.open...mechanismOfAction
| - The biological actions of rhPTH are mediated through binding to at least two distinct high- affinity cell-surface receptors specific for the N-terminal and C-terminal regions of the molecule, both of which are required for normal bone metabolism. The N-terminal portion of the molecule is primarily responsible for the bone building effects of parathyroid hormone. The C-terminal portion of the molecule has antiresorptive activity and is necessary for normal regulation of N-terminal fragment activity. (en)
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| http://linked.open...outeOfElimination
| - Not excreted from the body in its intact form. Circulating carboxy-terminal fragments are filtered by the kidney, but are subsequently broken down into even smaller fragments during tubular reuptake. (en)
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| http://linked.open.../drugbank/synonym
| - Parathyroid hormone (en)
- PTH(1-84) (en)
- Parathormone (human recombinant) (en)
- Parathyroid hormone (r.E.coli) (en)
- hPTH (en)
- hPTH(1-84) (en)
- rPTH (en)
- rPTH(1-84) (en)
- rhPTH (en)
- rhPTH(1-84) (en)
- Parathormone (en)
- Parathyrin (en)
- PTH (en)
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| http://linked.open...umeOfDistribution
| - The volume of distribution at steady-state following intravenous administration is approximately 5.4 liters. Intersubject variability is about 40%. (en)
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| http://linked.open...ynthesisReference
| - Robert L. Colescott, Geoffrey W. Tregear, "Synthesis of peptides with parathyroid hormone activity." U.S. Patent US4105602, issued May, 1977. (en)
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| http://linked.open...Molecular-Formula
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| http://linked.open.../Molecular-Weight
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| http://linked.open...l/drug/hasATCCode
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| http://linked.open...ugbank/absorption
| - The absolute bioavailability of 100 micrograms of Preotact after subcutaneous administration in the abdomen is 55%. (en)
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| http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
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| http://linked.open...casRegistryNumber
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| http://linked.open...rugbank/clearance
| - PTH is rapidly cleared from plasma, primarily by Kupffer cells in the liver. To a lesser extent, PTH is cleared by filtration and reabsorption by the kidney. (en)
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