About: Epicept NP-1

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description	EpiCept NP-1 is a prescription topical analgesic cream designed to provide effective, long-term relief from the pain of peripheral neuropathies. Peripheral neuropathies are medical conditions caused by damage to the nerves in the peripheral nervous system. The peripheral nervous system includes nerves that run from the brain and spinal cord to the rest of the body. EpiCept NP-1 Cream is a patented formulation containing two FDA-approved drugs, amitriptyline (a widely-used antidepressant) and ketamine (an NMDA antagonist that is used as an anesthetic). (en)
http://linked.open...generalReferences	# Sandroni P, Davis MD: Combination gel of 1% amitriptyline and 0.5% ketamine to treat refractory erythromelalgia pain: a new treatment option? Arch Dermatol. 2006 Mar;142(3):283-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16549702 # Lynch ME, Clark AJ, Sawynok J, Sullivan MJ: Topical amitriptyline and ketamine in neuropathic pain syndromes: an open-label study. J Pain. 2005 Oct;6(10):644-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16202956 # Lynch ME, Clark AJ, Sawynok J, Sullivan MJ: Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. Anesthesiology. 2005 Jul;103(1):140-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15983466 # Oatway M, Reid A, Sawynok J: Peripheral antihyperalgesic and analgesic actions of ketamine and amitriptyline in a model of mild thermal injury in the rat. Anesth Analg. 2003 Jul;97(1):168-73, table of contents. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12818961 (en)
http://linked.open...gy/drugbank/group	investigational (en)
http://linked.open...ugbank/indication	Investigated for use/treatment in neuropathy (diabetic) and pain (acute or chronic). (en)
sameAs	Epicept NP-1
Title	Epicept NP-1 (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB05492/identifier/chemspider/4440796 http://linked.opendata.cz/resource/drugbank/drug/DB05492/identifier/drugbank/DB05492 http://linked.opendata.cz/resource/drugbank/drug/DB05492/identifier/pdb/NP1 http://linked.opendata.cz/resource/drugbank/drug/DB05492/identifier/pubchem-compound/5276854
http://linked.open...mechanismOfAction	The mechanism(s) of action are unclear for Epicept. Both ketamine and amitriptyline inhibit N-methyl-D-aspartate receptors in neuronal preparations and may be involved in sensitization of tetrodotoxin-resistant Na+ currents in nociceptors by blocking Na+ channels. In producing antihyperalgesia with pretreatment, but not posttreatment, regimens, ketamine and amitriptyline resemble the profile of a µ-opioid receptor agonist. In addition to the above effects, amitriptyline also inhibits noradrenaline, 5-HT, and adenosine uptake; inter-acts with opioid mechanisms; blocks Ca2+ channels; and blocks cholinergic, histamine H1, 5-HT2, and {alpha}-adrenergic receptors. Accordingly there are many possible mechanisms at work. (en)
http://linked.open...drugbank/toxicity	Mild sensitivity at application site (en)
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