About: SCV-07     Goto   Sponge   NotDistinct   Permalink

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http://linked.open...gbank/description
  • SCV-07 (g -D-glutamyl-L-tryptophan) is a novel synthetic dipeptide that acts broadly on the Toll-like receptor pathway. It has been shown to stimulate T-lymphocyte differentiation, macrocytic phagocytosis, and specific immune responses, and enhance IL-2 and INF-g production. Due to this preferential activation of Th1 cytokine production, SCV-07 may show utility in treatment of tuberculosis. It can be administered orally or subcutaneously. In independent studies, treatment of tuberculosis with SCV-07 improved clearance of mycobacteria, improved cavity healing, improvements in immune parameters and reduced symptoms (fever, weakness, sweating, dry cough, productive cough, dyspnea, chest pain, tachycardia) without any adverse local or general effects. SCV-07 has shown efficacy in treating various viral and bacterial infections. (en)
http://linked.open...generalReferences
  • # Aspinall RJ, Pockros PJ: SCV-07 (SciClone Pharmaceuticals/Verta). Curr Opin Investig Drugs. 2006 Feb;7(2):180-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16499289 # Suzuki H, Kato K, Kumagai H: Development of an efficient enzymatic production of gamma-D-glutamyl-L-tryptophan (SCV-07), a prospective medicine for tuberculosis, with bacterial gamma-glutamyltranspeptidase. J Biotechnol. 2004 Aug 5;111(3):291-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15246665 # Bayes M, Rabasseda X, Prous JR: Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Jun;25(5):387-408. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12851663 # Orellana C: Immune system stimulator shows promise against tuberculosis. Lancet Infect Dis. 2002 Dec;2(12):711. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12467673 (en)
http://linked.open...gy/drugbank/group
  • investigational (en)
http://linked.open...ugbank/indication
  • Investigated for use/treatment in hepatitis (viral, C), infectious and parasitic disease (unspecified), and tuberculosis. (en)
sameAs
Title
  • SCV-07 (en)
adms:identifier
http://linked.open...mechanismOfAction
  • SCV-07 (g -D-glutamyl-L-tryptophan) has broad effects on the Toll-like receptor (TLR) pathway. (en)
http://linked.open...drugbank/toxicity
  • No adverse effects were observed in any patients participating in clinical trials. (en)
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http://linked.open.../affectedOrganism
  • Hepatitis C virus, RSV and other RNA/DNA viruses (en)
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http://linked.open...bank/Rule-of-Five
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http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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