About: AS-3201

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	AS-3201 is a structurally novel and stereospecifically potent aldose reductase (AKR1B; EC 1.1.1.21) inhibitor, which contains a succinimide ring that undergoes ring-opening at physiological pH levels. (en)
http://linked.open...generalReferences	# Bril V, Buchanan RA: Long-term effects of ranirestat (AS-3201) on peripheral nerve function in patients with diabetic sensorimotor polyneuropathy. Diabetes Care. 2006 Jan;29(1):68-72. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16373898 (en)
http://linked.open...gy/drugbank/group	investigational (en)
http://linked.open...ugbank/indication	Investigated for use/treatment in neuropathy (diabetic). (en)
sameAs	AS-3201
Title	AS-3201 (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB05327/identifier/bindingdb/50067407 http://linked.opendata.cz/resource/drugbank/drug/DB05327/identifier/chemspider/135685 http://linked.opendata.cz/resource/drugbank/drug/DB05327/identifier/drugbank/DB05327 http://linked.opendata.cz/resource/drugbank/drug/DB05327/identifier/pubchem-compound/153948
http://linked.open...mechanismOfAction	AS-3201 alleviates diabetic neuropathy, a complication of diabetes, by inhibiting aldose reductase and thereby inhibiting the accumulation of intracellular sorbitol that causes diabetic neuropathy. This drug has a stronger inhibitory effect and is longer acting compared to other drugs in this therapeutic area. AS-3201 showed good penetration into the nerve tissue, resulting in dose-dependent inhibition of intraneural accumulation of sorbitol and fructose in a clinical study. (en)
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