About: Beraprost     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Beraprost is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary hypertension. It is also being studied for use in avoiding reperfusion injury. (en)
http://linked.open...generalReferences
  • # Lin H, Lee JL, Hou HH, Chung CP, Hsu SP, Juan SH: Molecular mechanisms of the antiproliferative effect of beraprost, a prostacyclin agonist, in murine vascular smooth muscle cells. J Cell Physiol. 2007 Jul 9;. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17620284 # Melian EB, Goa KL: Beraprost: a review of its pharmacology and therapeutic efficacy in the treatment of peripheral arterial disease and pulmonary arterial hypertension. Drugs. 2002;62(1):107-33. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11790158 (en)
http://linked.open...gy/drugbank/group
  • investigational (en)
http://linked.open...drugbank/halfLife
  • 35–40 minutes (en)
http://linked.open...ugbank/indication
  • For the treatment of pulmonary hypertension. (en)
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Title
  • Beraprost (en)
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http://linked.open...mechanismOfAction
  • Beraprost acts by binding to prostacyclin membrane receptors ultimately inhibiting the release of Ca<sup>2+</sup> from intracellular storage sites. This reduction in the influx of Ca<sup>2+</sup> has been postulated to cause relaxation of the smooth muscle cells and vasodilation. (en)
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http://linked.open...ugbank/absorption
  • Oral bioavailability is 50–70%. (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 88430-50-6 (en)
http://linked.open...k/Bioavailability
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