About: Azimilide

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Azimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of the delayed rectifier cardiac potassium channels. It is not approved for use in any country, but is currently in clinical trials in the United States. (en)
http://linked.open...generalReferences	# Schmitt H, Cabo C, Coromilas JC, Wit AL: Effects of azimilide, a new class III antiarrhythmic drug, on reentrant circuits causing ventricular tachycardia and fibrillation in a canine model of myocardial infarction. J Cardiovasc Electrophysiol. 2001 Sep;12(9):1025-33. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11573692 # Abrol R, Page RL: Azimilide dihydrochloride: a new class III anti-arrhythmic agent. Expert Opin Investig Drugs. 2000 Nov;9(11):2705-15. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11060832 # Tran HT: Azimilide dihydrochloride: a unique class III antiarrhythmic agent. Heart Dis. 1999 May-Jun;1(2):114-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11720612 # Toothaker RD, Corey AE, Valentine SN, Agnew JR, Parekh N, Moehrke W, Thompson GA, Powell JH: Influence of coadministration on the pharmacokinetics of azimilide dihydrochloride and digoxin. J Clin Pharmacol. 2005 Jul;45(7):773-80. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15951467 # Riley P, Figary PC, Entwisle JR, Roe AL, Thompson GA, Ohashi R, Ohashi N, Moorehead TJ: The metabolic profile of azimilide in man: in vivo and in vitro evaluations. J Pharm Sci. 2005 Sep;94(9):2084-95. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16052551 (en)
http://linked.open...gy/drugbank/group	investigational (en)
http://linked.open...ugbank/indication	Investigated for use/treatment in arrhythmia and atrial fibrillation. (en)
sameAs	Azimilide
Title	Azimilide (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB04957/identifier/bindingdb/50117913 http://linked.opendata.cz/resource/drugbank/drug/DB04957/identifier/chemspider/7845470 http://linked.opendata.cz/resource/drugbank/drug/DB04957/identifier/drugbank/DB04957 http://linked.opendata.cz/resource/drugbank/drug/DB04957/identifier/kegg-compound/C13777 http://linked.opendata.cz/resource/drugbank/drug/DB04957/identifier/pubchem-compound/9571004 http://linked.opendata.cz/resource/drugbank/drug/DB04957/identifier/pubchem-substance/14833668 http://linked.opendata.cz/resource/drugbank/drug/DB04957/identifier/wikipedia/Azimilide
http://linked.open...mechanismOfAction	The mechanism of action of azimilide is to block both the slowly conducting (I(Ks)) and rapidly conducting (I(Kr)) rectifier potassium currents in cardiac cells. This differs from other class III agents that block I(Kr) exclusively or in combination with sodium, calcium, or transient outward (I(to)) potassium current channels. It also has blocking effects on sodium (I(Na)) and calcium currents (I(CaL)). Its effects on reentrant circuits in infarct border zones causing ventricular tachyarrhythmias are unknown. (en)
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http://linked.open...ugbank/absorption	Excellent oral absorption. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	149908-53-2 (en)
http://linked.open...drugbank/category	(en)
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