About: Cilansetron     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Cilansetron is a drug that is a 5HT-3 antagonist currently under trial phase in the EU and US. It is manufactured by Solvay Pharmaceuticals INC. [Wikipedia] (en)
http://linked.open...generalReferences
  • # Chey WD, Cash BD: Cilansetron: a new serotonergic agent for the irritable bowel syndrome with diarrhoea. Expert Opin Investig Drugs. 2005 Feb;14(2):185-93. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15757394 # : Cilansetron: KC 9946. Drugs R D. 2005;6(3):169-73. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15869320 # Tack J, Fried M, Houghton LA, Spicak J, Fisher G: Systematic review: the efficacy of treatments for irritable bowel syndrome--a European perspective. Aliment Pharmacol Ther. 2006 Jul 15;24(2):183-205. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16842448 (en)
http://linked.open...gy/drugbank/group
  • investigational (en)
http://linked.open...drugbank/halfLife
  • The elimination half-life after 4- and 8-mg oral doses administered 3 times daily for 6 days was reported to be 1.6 to 1.9 hours. (en)
http://linked.open...ugbank/indication
  • For the treatment of symptoms associated with irritable bowel syndrome. (en)
sameAs
Title
  • Cilansetron (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Cilansetron is a potent and selective 5-HT<sub>3</sub> receptor antagonist. 5-HT<sub>3</sub> receptors are nonselective cation channels that are extensively distributed on enteric neurons in the human gastrointestinal tract, as well as other peripheral and central locations. Activation of these channels and the resulting neuronal depolarization affect the regulation of visceral pain, colonic transit and gastrointestinal secretions, processes that relate to the pathophysiology of irritable bowel syndrome (IBS). 5-HT<sub>3</sub> receptor antagonists such as cilansetron inhibit activation of non-selective cation channels which results in the modulation of the enteric nervous system. (en)
http://linked.open...ugbank/IUPAC-Name
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http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
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http://linked.open.../Water-Solubility
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http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • Rapidly absorbed orally with a bioavailability of greater than 80% in rats. (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 120635-74-7 (en)
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...k/Number-of-Rings
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http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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