About: Lysergic Acid Diethylamide

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
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http://linked.open...gbank/description	Debate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by experimental evidence. Some say HPPD is a manifestation of post-traumatic stress disorder, not related to the direct action of LSD on brain chemistry, and varies according to the susceptibility of the individual to the disorder. Many emotionally intense experiences can lead to flashbacks when a person is reminded acutely of the original experience. However, not all published case reports of chronic flashbacks appear to describe an anxious hyper-vigilant state reminiscent of post-traumatic stress disorder. (en)
http://linked.open...generalReferences	# GREINER T, BURCH NR, EDELBERG R: Psychopathology and psychophysiology of minimal LSD-25 dosage; a preliminary dosage-response spectrum. AMA Arch Neurol Psychiatry. 1958 Feb;79(2):208-10. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/13497365 # AGHAJANIAN GK, BING OH: PERSISTENCE OF LYSERGIC ACID DIETHYLAMIDE IN THE PLASMA OF HUMAN SUBJECTS. Clin Pharmacol Ther. 1964 Sep-Oct;5:611-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14209776 # Papac DI, Foltz RL: Measurement of lysergic acid diethylamide (LSD) in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry. J Anal Toxicol. 1990 May-Jun;14(3):189-90. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2374410 # Nichols DE: Hallucinogens. Pharmacol Ther. 2004 Feb;101(2):131-81. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14761703 # Jacobs BL, Heym J, Rasmussen K: Raphe neurons: firing rate correlates with size of drug response. Eur J Pharmacol. 1983 Jun 3;90(2-3):275-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6873185 # AGHAJANIAN GK, BING OH: PERSISTENCE OF LYSERGIC ACID DIETHYLAMIDE IN THE PLASMA OF HUMAN SUBJECTS. Clin Pharmacol Ther. 1964 Sep-Oct;5:611-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14209776 (en)
http://linked.open...gy/drugbank/group	illicit (en) withdrawn (en)
http://linked.open...drugbank/halfLife	3 hours (en)
sameAs	Lysergic Acid Diethylamide Lysergic Acid Diethylamide
Title	Lysergic Acid Diethylamide (en)
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http://linked.open.../drugbank/synonym	(+)-LSD (en) (+)-lysergic acid diethylamide (en) D-LSD (en) D-LSD-25 (en) D-lysergic acid dethylamide (en) D-lysergic acid diethylamide (en) D-lysergic acid n,n-diethylamide (en) Dextrolysergic acid diethylamide (en) LSD (en) LSD-25 (en) Lysergamid (en) Lysergamide (en) Lysergaure diethylamid (en) Lysergic acid amide (en) Lysergic acid diethylamide-25 (en) Lysergide (en) N,n-diethyl-d-lysergamide (en) N,n-diethyllysergamide (en) n,n-diethyl-(+)-lysergamide (en) N,N-Diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide (en) 9,10-Didehydro-N,N-diethyl-6-methylergoline-8b-carboxamide (en) Diethylamid kyseliny lysergove (en) Lysergidum (en)
http://linked.open...drugbank/toxicity	Estimates for the lethal dosage (LD50) of LSD range from 200 µg/kg to more than 1 mg/kg of human body mass, though most sources report that there are no known human cases of such an overdose. (en)
http://linked.open...ynthesisReference	Jean-Luc Henri Sigier Emmanuel, "Device for maintaining the inner surface of gun barrels and method for producing same." U.S. Patent US5657570, issued September, 1918. (en)
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http://linked.open...ugbank/absorption	Rapidly absorbed. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	50-37-3 (en)
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