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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...generalReferences
  • # Wong MS, Delansorne R, Man RY, Vanhoutte PM: Vitamin D derivatives acutely reduces endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol. 2008 May 16;. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18487433 # Eelen G, Verlinden L, Van Camp M, Claessens F, De Clercq P, Vandewalle M, Bouillon R, Verstuyf A: Altered Vitamin D receptor-coactivator interactions reflect superagonism of Vitamin D analogs. J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):65-8. Epub 2005 Jul 20. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16039117 # Company Website "Link":http://www.hybrigenics.com/Pharma/Pharma-Content/Inecalcitol-Development.html (en)
http://linked.open...gy/drugbank/group
  • experimental (en)
http://linked.open...ugbank/indication
  • Investigated for use/treatment in prostate cancer, psoriasis and hyperparathyroidism. (en)
sameAs
Title
  • Inecalcitol (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Inecalcitol is an analogue of calcitriol, the naturally active metabolite of vitamin D. Calcitriol and their analogues activate the vitamin D receptor (VDR). Vitamin D has a major role in regulating calcium absorption from the gut, storage in mineral form in the bones, and excretion by the kidney and effectively prevents rickets in infants. Vitamin D and calcitriol can cause hypercalcemia at high or frequently repeated doses; in turn, hypercalcemia can cause kidney toxicity by accumulation of calcium-containing micro-crystals and heart and muscle dysfunction by impairing contractions. [Hybrigenics Website] The mechanism of action is currently unknown, but it is proposed that inecalcitol exerts its superagonistic action through enhancing coactivator binding by the VDR. (en)
http://linked.open.../drugbank/synonym
  • 19-nor-14-epi-23-yne-1,25 dihydroxyvitamin D3 (en)
  • TX522 (en)
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http://linked.open...bank/Rule-of-Five
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http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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