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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Bifonazole is an azole antifungal drug. [Wikipedia] (en)
http://linked.open...generalReferences
  • # Watanabe S, Takahashi H, Nishikawa T, Takiuchi I, Higashi N, Nishimoto K, Kagawa S, Yamaguchi H, Ogawa H: A comparative clinical study between 2 weeks of luliconazole 1% cream treatment and 4 weeks of bifonazole 1% cream treatment for tinea pedis. Mycoses. 2006 May;49(3):236-41. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16681817 # Cho KJ, Su W, Chen WC, Law YP, Fang HC, Liu CP, Cheng JS, Lee KC, Lo YK, Chang HT, Huang JK, Jan CR: Mechanism of bifonazole-induced [Ca2+]i increases in MDCK renal tubular cells. Chin J Physiol. 2001 Sep 30;44(3):97-101. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11767287 # Tanuma H, Doi M, Sato N, Nishiyama S, Abe M, Kume H, Katsuoka K: Bifonazole (Mycospor cream) in the treatment of moccasin-type tinea pedis. Comparison between combination therapy of bifonazole cream + 10% urea ointment (Urepearl) and occlusive dressing therapy with the same agents. Mycoses. 2000;43(3-4):129-37. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10907343 # Berg D, Regel E, Harenberg HE, Plempel M: Bifonazole and clotrimazole. Their mode of action and the possible reason for the fungicidal behaviour of bifonazole. Arzneimittelforschung. 1984;34(2):139-46. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6372801 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • 1-2 hours (en)
http://linked.open...ugbank/indication
  • Used for the treatment of various topical fungal infections, including athlete's foot (tinea pedis). (en)
sameAs
Title
  • Bifonazole (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Bifonazole works by inhibiting the production of a substance called ergosterol, which is an essential component of fungal cell membranes.It acts to destabilize the fungal cyctochrome p450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear. The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As bifonazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi. (en)
http://linked.open.../drugbank/synonym
  • Mycospor (en)
  • (+-)-1-(p,alpha-Diphenylbenzyl)imidazole (en)
  • 1-((4-Biphenylyl)phenylmethyl)-1H-imidazole (en)
  • 1-(alpha-(4-Biphenylyl)benzyl)imidazole (en)
  • 1-(p,alpha-Diphenylbenzyl)imidazole (en)
  • Bay h 4502 (en)
  • Trifonazole (en)
  • (+-)1-([1,1'-Biphenyl]-4-ylphenylmethyl)-1H-imidazole (en)
  • Bifonazol (en)
  • Bifonazolum (en)
http://linked.open...ynthesisReference
  • Regal, E., Draber, W., Buchel, K.H.and Plempel, M.; U.S. Patent 4,118,487; October 3,1978; assigned to Bayer A.G. (en)
http://linked.open...y/mesh/hasConcept
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • Very low absorption following topical administration (0.6% of an applied dose). In cases of skin lesions absorption is increased (2.5%). (en)
http://linked.open.../affectedOrganism
  • Fungi (en)
http://linked.open...casRegistryNumber
  • 60628-96-8 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...-strongest-basic-
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