About: Apramycin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Apramycin is an aminoglycoside antibiotic and has a bactericidal action against many gram-negative bacteria. Apramycin is a structurally unique antibiotic that contains a bicyclic sugar moiety and a monosubstituted deoxystreptamine. It is not approved for use in humans. (en)
http://linked.open...generalReferences	# Hermann T, Tereshko V, Skripkin E, Patel DJ: Apramycin recognition by the human ribosomal decoding site. Blood Cells Mol Dis. 2007 May-Jun;38(3):193-8. Epub 2007 Jan 29. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17258916 # Kondo J, Francois B, Urzhumtsev A, Westhof E: Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding site complexed with apramycin. Angew Chem Int Ed Engl. 2006 May 12;45(20):3310-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16596680 # Han Q, Zhao Q, Fish S, Simonsen KB, Vourloumis D, Froelich JM, Wall D, Hermann T: Molecular recognition by glycoside pseudo base pairs and triples in an apramycin-RNA complex. Angew Chem Int Ed Engl. 2005 Apr 29;44(18):2694-700. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15849690 (en)
http://linked.open...gy/drugbank/group	experimental (en)
http://linked.open...ugbank/indication	For the treatment of bacterial infections in animals. (en)
sameAs	Apramycin Apramycin
Title	Apramycin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB04626/identifier/drugbank/DB04626 http://linked.opendata.cz/resource/drugbank/drug/DB04626/identifier/kegg-compound/C01555 http://linked.opendata.cz/resource/drugbank/drug/DB04626/identifier/kegg-drug/D02322 http://linked.opendata.cz/resource/drugbank/drug/DB04626/identifier/pdb/AM2 http://linked.opendata.cz/resource/drugbank/drug/DB04626/identifier/pubchem-compound/3081545 http://linked.opendata.cz/resource/drugbank/drug/DB04626/identifier/pubchem-substance/46509143 http://linked.opendata.cz/resource/drugbank/drug/DB04626/identifier/wikipedia/Apramycin
http://linked.open...mechanismOfAction	Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A base pairs and a bulged-out adenine. The binding mode of apramycin at the human decoding-site RNA is distinct from aminoglycoside recognition of the bacterial target, suggesting a molecular basis for the actions of apramycin in eukaryotes and bacteria. (en)
http://linked.open.../drugbank/synonym	Nebramycin II (en)
http://linked.open...ynthesisReference	Koji Tomita, Hiroshi Tsukiura, Hiroshi Kawaguchi, "Fermentation process for producing apramycin and nebramycin factor V'." U.S. Patent US4032404, issued December, 1974. (en)
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http://linked.open.../affectedOrganism	Enteric bacteria and other eubacteria (en)
http://linked.open...casRegistryNumber	37321-09-8 (en)
http://linked.open...drugbank/category	(en)
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