About: Afimoxifene

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Afimoxifene (4-Hydroxytamoxifen, trade name TamoGel) is a new estrogen inhibitor under investigation for a variety of estrogen-dependent conditions, including cyclic breast pain and gynecomastia. TamoGel is formulated using Enhanced Hydroalcoholic Gel (EHG) Technology. This technology enables percutaneous delivery of drugs that cannot be delivered orally. It is being developed by Ascent Therapeutics. (en)
http://linked.open...generalReferences	# Bollig A, Xu L, Thakur A, Wu J, Kuo TH, Liao JD: Regulation of intracellular calcium release and PP1alpha in a mechanism for 4-hydroxytamoxifen-induced cytotoxicity. Mol Cell Biochem. 2007 Nov;305(1-2):45-54. Epub 2007 Jul 24. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17646931 # Mansel R, Goyal A, Nestour EL, Masini-Eteve V, O'Connell K: A phase II trial of Afimoxifene (4-hydroxytamoxifen gel) for cyclical mastalgia in premenopausal women. Breast Cancer Res Treat. 2007 Dec;106(3):389-97. Epub 2007 Mar 10. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17351746 # Leblanc K, Sexton E, Parent S, Belanger G, Dery MC, Boucher V, Asselin E: Effects of 4-hydroxytamoxifen, raloxifene and ICI 182 780 on survival of uterine cancer cell lines in the presence and absence of exogenous estrogens. Int J Oncol. 2007 Feb;30(2):477-87. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17203231 # Cardoso CM, Almeida LM, Custodio JB: 4-Hydroxytamoxifen is a potent inhibitor of the mitochondrial permeability transition. Mitochondrion. 2002 Oct;1(6):485-95. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16120301 (en)
http://linked.open...gy/drugbank/group	investigational (en)
http://linked.open...ugbank/indication	For the potential treatment of menstrual-cycle related mastalgia, fibrocystic breast disease, breast disease, gynecomastia and Keloid scarring. (en)
sameAs	Afimoxifene
Title	Afimoxifene (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB04468/identifier/bindingdb/20608 http://linked.opendata.cz/resource/drugbank/drug/DB04468/identifier/chemspider/4509087 http://linked.opendata.cz/resource/drugbank/drug/DB04468/identifier/drugbank/DB04468 http://linked.opendata.cz/resource/drugbank/drug/DB04468/identifier/pdb/OHT http://linked.opendata.cz/resource/drugbank/drug/DB04468/identifier/pubchem-compound/449459 http://linked.opendata.cz/resource/drugbank/drug/DB04468/identifier/pubchem-substance/7889566
http://linked.open...mechanismOfAction	Afimoxifene binds to estrogen receptors (ER), inducing a conformational change in the receptor. This results in a blockage or change in the expression of estrogen dependent genes. (en)
http://linked.open.../drugbank/synonym	4-Hydroxytamoxifen (en) 4-OHT (en) hydroxytamoxife (en)
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B5CB8-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B5CBE-363D-11E5-9242-09173F13E4C5
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http://linked.open...ugbank/absorption	Absorbed following topical application. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	65213-48-1 (en)
http://linked.open...drugbank/category	(en)
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http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B5CC7-363D-11E5-9242-09173F13E4C5

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