About: Eniluracil

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Eniluracil, which was previously under development by GlaxoSmithKline (GSK), is being developed by Adherex to enhance the therapeutic value and effectiveness of 5-fluorouracil (5-FU), one of the world’s most widely-used oncology agents. 5-FU is widely used in the U.S. and is often first or second line therapy for a variety of cancers including colorectal, breast, gastric, head and neck, ovarian and basal cell cancer of the skin. Eniluracil could improve 5-FU by increasing its effectiveness, reducing its side effects and/or making it orally available. Eniluracil has received Orphan Drug status from the FDA for the treatment of hepatocellular cancer in combination with fluoropyrimidines (including 5-FU). (en)
http://linked.open...generalReferences	# Czito BG, Hong TJ, Cohen DP, Petros WP, Tyler DS, Pappas TN, Yu D, Lee CG, Lockhart AC, Morse MA, Fernando N, Hurwitz HI: A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract. Cancer Invest. 2006 Feb;24(1):9-17. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16466986 # Czito BG, Hong TJ, Cohen DP, Tyler DS, Lee CG, Anscher MS, Ludwig KA, Seigler HF, Mantyh C, Morse MA, Lockhart AC, Petros WP, Honeycutt W, Spector NL, Ertel PJ, Mangum SG, Hurwitz HI: A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon. Int J Radiat Oncol Biol Phys. 2004 Mar 1;58(3):779-85. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14967434 # Yip D, Karapetis C, Strickland AH, Steer C, Holford C, Knight S, Harper P: A dose-escalating study of oral eniluracil/5-fluorouracil plus oxaliplatin in patients with advanced gastrointestinal malignancies. Ann Oncol. 2003 Jun;14(6):864-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12796023 (en)
http://linked.open...gy/drugbank/group	investigational (en)
http://linked.open...ugbank/indication	For the treatment of cancer in combination with 5-fluorouracil. (en)
sameAs	Eniluracil
Title	Eniluracil (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB03516/identifier/bindingdb/50124202 http://linked.opendata.cz/resource/drugbank/drug/DB03516/identifier/chemspider/39327 http://linked.opendata.cz/resource/drugbank/drug/DB03516/identifier/drugbank/DB03516 http://linked.opendata.cz/resource/drugbank/drug/DB03516/identifier/kegg-drug/D03998 http://linked.opendata.cz/resource/drugbank/drug/DB03516/identifier/pubchem-compound/43157 http://linked.opendata.cz/resource/drugbank/drug/DB03516/identifier/pubchem-substance/12014705
http://linked.open...mechanismOfAction	Normally, 5-FU is rapidly broken down in the body by an enzyme known as dihydropyrimidine dehydrogenase (DPD). Eniluracil irreversibly inhibits DPD, thereby substantially slowing the breakdown of 5-FU and prolonging exposure of the tumor cells to the drug. (en)
http://linked.open.../drugbank/synonym	5-Ethynyluracil (en) 5-ethynyl-2,4(1H,3H)-Pyrimidinedione (en) Compound 776C (en)
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B4FCB-363D-11E5-9242-09173F13E4C5
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	59989-18-3 (en)
http://linked.open...drugbank/category	(en)
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