About: Equilin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	An estrogenic steroid produced by horses. It has a total of four double bonds in the A- and B-ring. High concentration of euilin is found in the urine of pregnant mares. [PubChem] Equilin is one of the estrogens present in the mixture of estrogens isolated from horse urine and marketed as Premarin. Premarin became the most commonly used form of estrogen for hormone replacement therapy in the United States of America. Estrone is the major estrogen in Premarin (about 50%) and equilin is present as about 25% of the total. Estrone is a major estrogen that is normally found in women. Equilin is not normally present in women, so there has been interest in the effects of equilin on the human body. [Wikipedia] The estrogens in Premarin are present mainly as "conjugates", modified chemical forms in which the active estrogen is coupled to another chemical group such as sulfate. Estrone sulfate is usually the major form of estrogen in women. After being taken into a woman's body, the conjugated estrogens of Premarin are converted to the active unconjugated estrogens or excreted from the woman's body. Estrone can be converted to estradiol, which is thought to be the major active estrogen in women. [Wikipedia] (en)
http://linked.open...generalReferences	# Sawicki MW, Erman M, Puranen T, Vihko P, Ghosh D: Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+. Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):840-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9927655 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and Advanced androgen-dependent carcinoma of the prostate (for palliation only) (en)
sameAs	Equilin Equilin
Title	Equilin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB02187/identifier/chebi/42309 http://linked.opendata.cz/resource/drugbank/drug/DB02187/identifier/chemspider/193995 http://linked.opendata.cz/resource/drugbank/drug/DB02187/identifier/drugbank/DB02187 http://linked.opendata.cz/resource/drugbank/drug/DB02187/identifier/kegg-compound/C14392 http://linked.opendata.cz/resource/drugbank/drug/DB02187/identifier/kegg-drug/D04041 http://linked.opendata.cz/resource/drugbank/drug/DB02187/identifier/pdb/EQI http://linked.opendata.cz/resource/drugbank/drug/DB02187/identifier/pubchem-compound/223368 http://linked.opendata.cz/resource/drugbank/drug/DB02187/identifier/pubchem-substance/46506633 http://linked.opendata.cz/resource/drugbank/drug/DB02187/identifier/wikipedia/Equilin
http://linked.open...mechanismOfAction	Estrogens enter the cells of responsive tissues (e.g., female organs, breasts, hypothalamus, pituitary) where they interact with a protein receptor, subsequently increasing the rate of synthesis of DNA, RNA, and some proteins. Estrogens decrease the secretion of gonadotropin-releasing hormone by the hypothalamus, reducing the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. (en)
http://linked.open.../drugbank/synonym	Equilin (en) 1,3,5,7-Estratetraen-3-ol-17-one (en) 7-Dehydroestrone (en) Dihydroequilenin (en)
http://linked.open.../drugbank/mixture	Premarin
http://linked.open...nk/proteinBinding	90% bound to plasma proteins (en)
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B45F8-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B45FE-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B45FD-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B45FA-363D-11E5-9242-09173F13E4C5
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http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B45FC-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B45F6-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B460E-363D-11E5-9242-09173F13E4C5
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http://linked.open...ugbank/absorption	Well absorbed. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	474-86-2 (en)
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B460A-363D-11E5-9242-09173F13E4C5
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http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B460B-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B45F9-363D-11E5-9242-09173F13E4C5
http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B4606-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B4607-363D-11E5-9242-09173F13E4C5

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