About: Thiothixene

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About: Thiothixene Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5D64-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5D65-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5D66-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5D67-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5D68-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	10-20 hours (en)
http://linked.open...ugbank/indication	For the management of schizophrenia. (en)
sameAs	Thiothixene Thiothixene
Title	Thiothixene (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01623/identifier/chemspider/819430 http://linked.opendata.cz/resource/drugbank/drug/DB01623/identifier/drugbank/DB01623 http://linked.opendata.cz/resource/drugbank/drug/DB01623/identifier/national-drug-code-directory/0049-5710-66 http://linked.opendata.cz/resource/drugbank/drug/DB01623/identifier/pharmgkb/PA451669 http://linked.opendata.cz/resource/drugbank/drug/DB01623/identifier/pubchem-compound/941651 http://linked.opendata.cz/resource/drugbank/drug/DB01623/identifier/pubchem-substance/46505564 http://linked.opendata.cz/resource/drugbank/drug/DB01623/identifier/wikipedia/Thiothixene
http://linked.open...mechanismOfAction	Thiothixene acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects). (en)
http://linked.open...drugbank/packager	Advanced Pharmaceutical Services Inc. American therapeutics inc Amneal pharmaceuticals ny llc Cm bundy co Cadista pharmaceuticals inc Contract pharmacal corp Actavis mid atlantic llc Pfizer Inc. Everylife GlaxoSmithKline Inc. Heather drug co inc Impax laboratories inc Inwood laboratories inc sub forest laboratories inc Ivax pharmaceuticals inc sub teva pharmaceuticals usa Sandoz Lannett co inc L perrigo co Marshall pharmacal corp
http://linked.open.../drugbank/synonym	Tiotixene (en) Thiothixene (en) Navane (en) (e)-thiothixene (en) Cis-thiothixene (en) Thiothixine (en) Tiotixeno (en) Tiotixenum (en)
http://linked.open...drugbank/toxicity	Symptoms of overdose include central nervous system depression, coma, difficulty swallowing, dizziness, drowsiness, head tilted to the side, low blood pressure, muscle twitching, rigid muscles, salivation, tremors, walking disturbances, and weakness. (en)
http://linked.open...k/foodInteraction	Avoid alcohol (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0021384
foaf:page	http://www.drugs.com/cdi/thiothixene.html http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/nav1285.shtml http://www.rxlist.com/cgi/generic/thiothix.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B5D6D-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B5D73-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B5D72-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5D6F-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5D70-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B5D71-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B5D6B-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B5D69-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B5D6C-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B5D6A-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Tiotixene
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B5D79-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B5D7A-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B5D74-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B5D75-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B5D77-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B5D76-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B5D78-363D-11E5-9242-09173F13E4C5
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	5591-45-7 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Ditropan 5 mg/5ml Syrup Apo-Oxybutynin 5 mg Tablet Mylan-Oxybutynin 5 mg Tablet Novo-Oxybutynin 5 mg Tablet Nu-Oxybutyn 5 mg Tablet Pms-Oxybutynin 5 mg Tablet Oxybutynin Chloride 5 mg tablet Navane 2 mg capsule
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B5D7E-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B5D80-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B5D81-363D-11E5-9242-09173F13E4C5
http://linked.open...k/Number-of-Rings	http://linked.opendata.cz/resource/drugbank/property/271B5D7D-363D-11E5-9242-09173F13E4C5
http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B5D7C-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B5D7F-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B5D6E-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B5D7B-363D-11E5-9242-09173F13E4C5

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