About: Pipotiazine

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About: Pipotiazine Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Pipotiazine has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It is used for the maintenance treatment of chronic non-agitated schizophrenic patients. Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation. (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For the maintenance treatment of chronic non-agitated schizophrenic patients. (en)
sameAs	Pipotiazine Pipotiazine
Title	Pipotiazine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01621/identifier/chemspider/56598 http://linked.opendata.cz/resource/drugbank/drug/DB01621/identifier/drugbank/DB01621 http://linked.opendata.cz/resource/drugbank/drug/DB01621/identifier/kegg-drug/D08385 http://linked.opendata.cz/resource/drugbank/drug/DB01621/identifier/pharmgkb/PA10158 http://linked.opendata.cz/resource/drugbank/drug/DB01621/identifier/pubchem-compound/62867 http://linked.opendata.cz/resource/drugbank/drug/DB01621/identifier/pubchem-substance/46508263
http://linked.open...mechanismOfAction	Pipotiazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects). (en)
http://linked.open.../drugbank/synonym	Pipothiazine (en) Piportil (en) Pipotiazina (en) Pipotiazinum (en)
http://linked.open...drugbank/toxicity	Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation. (en)
http://linked.open...k/foodInteraction	Avoid alcohol (en) Take with food to decrease irritation (en)
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B5D19-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B5D1F-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B5D1E-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5D1B-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5D1C-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B5D1D-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B5D17-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B5D15-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B5D18-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B5D16-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Pipotiazine
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B5D25-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B5D26-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B5D20-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B5D21-363D-11E5-9242-09173F13E4C5
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http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B5D22-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B5D24-363D-11E5-9242-09173F13E4C5
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	39860-99-6 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Apo-Clobazam 10 mg Tablet Piportil L4 25 mg/ml
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B5D2B-363D-11E5-9242-09173F13E4C5
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http://linked.open...k/Number-of-Rings	http://linked.opendata.cz/resource/drugbank/property/271B5D2A-363D-11E5-9242-09173F13E4C5
http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B5D29-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B5D2C-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B5D1A-363D-11E5-9242-09173F13E4C5
http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B5D27-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B5D28-363D-11E5-9242-09173F13E4C5

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