About: Alverine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Alverine is a smooth muscle relaxant. Smooth muscle is a type of muscle that is not under voluntary control; it is the muscle present in places such as the gut and uterus. Alverine acts directly on the muscle in the gut, causing it to relax. This prevents the muscle spasms which occur in the gut in conditions such as irritable bowel syndrome and diverticular disease. It is used to relieve cramps or spasms of the stomach and intestines. It is also useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to help relieve period pain. Alverine is formulated as the citrate salt (5982-87-6). (en)
http://linked.open...generalReferences	# Hayase M, Hashitani H, Suzuki H, Kohri K, Brading AF: Evolving mechanisms of action of alverine citrate on phasic smooth muscles. Br J Pharmacol. 2007 Dec;152(8):1228-38. Epub 2007 Oct 15. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17934514 # Wittmann T, Paradowski L, Ducrotte P, Bueno L, Andro Delestrain MC: Clinical trial: the efficacy of alverine citrate/simeticone combination on abdominal pain/discomfort in irritable bowel syndrome--a randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2010 Mar;31(6):615-24. Epub 2009 Dec 10. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20003095 # Ju D, Wang X, Xie Y: Dyclonine and alverine citrate enhance the cytotoxic effects of proteasome inhibitor MG132 on breast cancer cells. Int J Mol Med. 2009 Feb;23(2):205-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/19148544 # "Spasmonal Package Insert":http://www.medicines.org.uk/EMC/medicine/24562/SPC/ (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	The plasma half-life averages 0.8 hours for alverine and 5.7 hours for the active primary metabolite. (en)
http://linked.open...ugbank/indication	Used to relieve cramps or spasms of the stomach and intestines. It is also useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to help relieve period pain. Alverine citrate is also under investigation to increase the cytotoxic effects of the proteasome inhibitor MG132 on breast cancer cells. (en)
sameAs	Alverine Alverine
Title	Alverine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01616/identifier/chebi/518413 http://linked.opendata.cz/resource/drugbank/drug/DB01616/identifier/chemspider/3550 http://linked.opendata.cz/resource/drugbank/drug/DB01616/identifier/drugbank/DB01616 http://linked.opendata.cz/resource/drugbank/drug/DB01616/identifier/kegg-drug/D07440 http://linked.opendata.cz/resource/drugbank/drug/DB01616/identifier/pubchem-compound/3678 http://linked.opendata.cz/resource/drugbank/drug/DB01616/identifier/pubchem-substance/46506981 http://linked.opendata.cz/resource/drugbank/drug/DB01616/identifier/pharmgkb/PA164764505 http://linked.opendata.cz/resource/drugbank/drug/DB01616/identifier/wikipedia/Alverine
http://linked.open...outeOfElimination	High renal clearance of all metabolites indicating that they are eliminated by active renal secretion. (en)
http://linked.open.../drugbank/synonym	Bis(gamma-phenylpropyl)ethylamine (en) Di(phenylpropyl)ethylamine (en) N,N-Bis(3-phenylpropyl)ethylamine (en) N-Ethyl-3,3'-diphenyldipropylamine (en) N-Ethyl-3-phenyl-N-(3-phenylpropyl)-1-propanamine (en) N-Ethyl-N-(3-phenylpropyl)benzenepropanamine (en) Phenopropamine (en) Phenpropamine (en) Alverina (en) Alverinum (en)
http://linked.open...drugbank/toxicity	Can produce hypotension and atropine-like toxic effects. Fatality has occurred following overdose with very high doses. (en)
http://linked.open...ogy/drugbank/salt	(en)
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	150-59-4 (en)
http://linked.open...drugbank/category	(en)
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