| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - Methamphetamine is a psychostimulant and sympathomimetic drug. It is a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potential for addiction and abuse. (en)
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| http://linked.open...y/drugbank/dosage
| |
| http://linked.open...generalReferences
| - # Schepers RJ, Oyler JM, Joseph RE Jr, Cone EJ, Moolchan ET, Huestis MA: Methamphetamine and amphetamine pharmacokinetics in oral fluid and plasma after controlled oral methamphetamine administration to human volunteers. Clin Chem. 2003 Jan;49(1):121-32. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12507968 # McGregor C, Srisurapanont M, Jittiwutikarn J, Laobhripatr S, Wongtan T, White JM: The nature, time course and severity of methamphetamine withdrawal. Addiction. 2005 Sep;100(9):1320-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16128721 # Bennett BA, Hollingsworth CK, Martin RS, Harp JJ: Methamphetamine-induced alterations in dopamine transporter function. Brain Res. 1998 Jan 26;782(1-2):219-27. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9519266 # Hasan AA, Ciancio S: Relationship between amphetamine ingestion and gingival enlargement. Pediatr Dent. 2004 Sep-Oct;26(5):396-400. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15460293 # Shaner JW: Caries associated with methamphetamine abuse. J Mich Dent Assoc. 2002 Sep;84(9):42-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12271905 (en)
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| http://linked.open...gy/drugbank/group
| - approved (en)
- illicit (en)
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| http://linked.open...drugbank/halfLife
| - The biological half-life has been reported in the range of 4 to 5 hours. (en)
|
| http://linked.open...ugbank/indication
| - For the treatment of Attention Deficit Disorder with Hyperactivity (ADHD) and exogenous obesity. (en)
|
| sameAs
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| Title
| |
| adms:identifier
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| http://linked.open...mechanismOfAction
| - Methamphetamine enters the brain and triggers a cascading release of norepinephrine, dopamine and serotonin. To a lesser extent methamphetamine acts as a dopaminergic and adrenergic reuptake inhibitor and in high concentrations as a monamine oxidase inhibitor (MAOI). The mechanism of action involved in producing the beneficial behavioral changes seen in hyperkinetic children receiving methamphetamine is unknown. (en)
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| http://linked.open...drugbank/packager
| |
| http://linked.open...outeOfElimination
| - Excretion occurs primarily in the urine, the rate of which is dependent on urine pH. Between 30-54% of an oral dose is excreted in urine as unchanged methamphetamine and 10-23% as unchanged amphetamine. Following an intravenous dose, 45% is excreted as unchanged parent drug and 7% amphetamine. (en)
|
| http://linked.open.../drugbank/synonym
| - Methamphetamine (en)
- Methyl-beta-phenylisopropylamine (en)
- (+)-(S)-N-alpha-Dimethylphenethylamine (en)
- (+)-(S)-N-α-dimethylphenethylamine (en)
- (AlphaS)-N,alpha-dimethylbenzeneethanamine (en)
- (S)-N,alpha-Dimethylbenzeneethanamine (en)
- (S)-N,α-dimethylbenzeneethanamine (en)
- (αS)-N,α-dimethylbenzeneethanamine (en)
- Dextromethamphetamine (en)
- Metamfetaminum (en)
- Metanfetamina (en)
- Methamphetaminum (en)
- Métamfétamine (en)
- d-1-phenyl-2-methylaminopropane (en)
- d-N-methylamphetamine (en)
- d-deoxyephedrine (en)
- d-desoxyephedrine (en)
- d-phenylisopropylmethylamine (en)
- methyl-β-phenylisopropylamine (en)
|
| http://linked.open...drugbank/toxicity
| - Manifestations of acute overdosage with methamphetamine include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, panic states, hyperpyrexia, and rhabdomyolysis. Fatigue and depression usually follow the central stimulation. Cardiovascular effects include arrhythmias, hypertension or hypotension, and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea, and abdominal cramps. Fatal poisoning usually terminates in convulsions and coma. (en)
|
| http://linked.open...ogy/drugbank/salt
| |
| http://linked.open...ynthesisReference
| - Nobuyuki Shigetoh, Hiroshi Nakayama, Jinsei Miyazaki, Tadayasu Mitsumata, "Labelling colors for detecting cocaine or methamphetamine, method of preparing the same and detector for cocaine or methamphetamine." U.S. Patent US5571727, issued October, 1981. (en)
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| http://linked.open...y/mesh/hasConcept
| |
| foaf:page
| |
| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
| |
| http://linked.open...noisotopic-Weight
| |
| http://linked.open...y/drugbank/SMILES
| |
| http://linked.open.../Water-Solubility
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| http://linked.open...ogy/drugbank/logP
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| http://linked.open...ogy/drugbank/logS
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| http://linked.open...logy/drugbank/pKa
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| http://linked.open...nd-Acceptor-Count
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| http://linked.open...-Bond-Donor-Count
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| http://linked.open...drugbank/InChIKey
| |
| http://linked.open...urface-Area--PSA-
| |
| http://linked.open...nk/Polarizability
| |
| http://linked.open...bank/Refractivity
| |
| http://linked.open...atable-Bond-Count
| |
| http://linked.open...ugbank/absorption
| - Methamphetamine is rapidly absorbed from the gastrointestinal tract with peak methamphetamine concentrations occurring in 3.13 to 6.3 hours post ingestion. Methamphetamine is also well absorbed following inhalation and following intranasal administration. It is distributed to most parts of the body. Because methamphetamine has a high lipophilicity it is distributed across the blood brain barrier and crosses the placenta. (en)
|
| http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
|
| http://linked.open...casRegistryNumber
| |
| http://linked.open...drugbank/category
| |
| http://linked.open...gbank/containedIn
| |
| http://linked.open...k/Bioavailability
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| http://linked.open...bank/Ghose-Filter
| |
| http://linked.open...nk/MDDR-Like-Rule
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| http://linked.open...k/Number-of-Rings
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| http://linked.open...siological-Charge
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| http://linked.open...bank/Rule-of-Five
| |
| http://linked.open...tional-IUPAC-Name
| |
| http://linked.open...-strongest-basic-
| |
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