Attributes | Values |
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rdf:type
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http://linked.open...gbank/description
| - A hypnotic and sedative. Its use has been largely superseded by other drugs. [PubChem] (en)
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http://linked.open...gy/drugbank/group
| - approved (en)
- illicit (en)
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http://linked.open...drugbank/halfLife
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http://linked.open...ugbank/indication
| - For the treatment of insomnia. (en)
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sameAs
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Title
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adms:identifier
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http://linked.open...mechanismOfAction
| - Glutethimide seems to be a GABA agonist which helps induced sedation. It also induces CYP 2D6. When taken with codeine, it enables the body to convert higher amounts of the codeine (higher than the average 5 - 10%) to morphine. The general sedative effect also adds to the power of the combination. (en)
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http://linked.open...outeOfElimination
| - glutethimide is inactivated by conjugation and the metabolites are excreted in urine, only 2% of the parent substance is excreted in urine, up to 2% of the dose has been reported to be found in the faeces. (en)
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http://linked.open.../drugbank/synonym
| - Doriden (en)
- 2-Ethyl-2-phenylglutarimide (en)
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http://linked.open...drugbank/toxicity
| - In adults, death has been reported after 5 g. The usual lethal dose is 10 to 20g, although survival after a dose of 28 g has been reported. (en)
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http://linked.open...k/foodInteraction
| - Avoid alcohol. (en)
- Take without regard to meals. (en)
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http://linked.open...ynthesisReference
| - Hoffmann, K. and Tagmann, E.; U.S. Patent 2,673,205; March 23, 1954; assigned to Ciba Pharmaceutical Products, Inc. (en)
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http://linked.open...y/mesh/hasConcept
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http://linked.open...ugbank/IUPAC-Name
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http://linked.open...gy/drugbank/InChI
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http://linked.open...Molecular-Formula
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http://linked.open.../Molecular-Weight
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http://linked.open...noisotopic-Weight
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http://linked.open...y/drugbank/SMILES
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http://linked.open.../Water-Solubility
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http://linked.open...ogy/drugbank/logP
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http://linked.open...ogy/drugbank/logS
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http://linked.open...logy/drugbank/pKa
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http://linked.open...l/drug/hasATCCode
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http://linked.open...nd-Acceptor-Count
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http://linked.open...-Bond-Donor-Count
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http://linked.open...drugbank/InChIKey
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http://linked.open...urface-Area--PSA-
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http://linked.open...nk/Polarizability
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http://linked.open...bank/Refractivity
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http://linked.open...atable-Bond-Count
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http://linked.open...ugbank/absorption
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http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
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http://linked.open...casRegistryNumber
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http://linked.open...drugbank/category
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http://linked.open...k/Bioavailability
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http://linked.open...bank/Ghose-Filter
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http://linked.open...nk/MDDR-Like-Rule
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http://linked.open...ank/Melting-Point
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http://linked.open...k/Number-of-Rings
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http://linked.open...siological-Charge
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http://linked.open...bank/Rule-of-Five
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http://linked.open...tional-IUPAC-Name
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http://linked.open...strongest-acidic-
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http://linked.open...-strongest-basic-
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