About: Glutethimide     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • A hypnotic and sedative. Its use has been largely superseded by other drugs. [PubChem] (en)
http://linked.open...gy/drugbank/group
  • approved (en)
  • illicit (en)
http://linked.open...drugbank/halfLife
  • 10-12 hours (en)
http://linked.open...ugbank/indication
  • For the treatment of insomnia. (en)
sameAs
Title
  • Glutethimide (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Glutethimide seems to be a GABA agonist which helps induced sedation. It also induces CYP 2D6. When taken with codeine, it enables the body to convert higher amounts of the codeine (higher than the average 5 - 10%) to morphine. The general sedative effect also adds to the power of the combination. (en)
http://linked.open...outeOfElimination
  • glutethimide is inactivated by conjugation and the metabolites are excreted in urine, only 2% of the parent substance is excreted in urine, up to 2% of the dose has been reported to be found in the faeces. (en)
http://linked.open.../drugbank/synonym
  • Doriden (en)
  • 2-Ethyl-2-phenylglutarimide (en)
http://linked.open...drugbank/toxicity
  • In adults, death has been reported after 5 g. The usual lethal dose is 10 to 20g, although survival after a dose of 28 g has been reported. (en)
http://linked.open...k/foodInteraction
  • Avoid alcohol. (en)
  • Take without regard to meals. (en)
http://linked.open...ynthesisReference
  • Hoffmann, K. and Tagmann, E.; U.S. Patent 2,673,205; March 23, 1954; assigned to Ciba Pharmaceutical Products, Inc. (en)
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  • Variable (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 77-21-4 (en)
http://linked.open...drugbank/category
  • (en)
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