About: Digitoxin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
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http://linked.open...gbank/description	A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) (en)
http://linked.open...generalReferences	# Belz GG, Breithaupt-Grogler K, Osowski U: Treatment of congestive heart failure--current status of use of digitoxin. Eur J Clin Invest. 2001;31 Suppl 2:10-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11525233 # Kurowski V, Iven H, Djonlagic H: Treatment of a patient with severe digitoxin intoxication by Fab fragments of anti-digitalis antibodies. Intensive Care Med. 1992;18(7):439-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1469187 # Johansson S, Lindholm P, Gullbo J, Larsson R, Bohlin L, Claeson P: Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells. Anticancer Drugs. 2001 Jun;12(5):475-83. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11395576 # Hippius M, Humaid B, Sicker T, Hoffmann A, Gottler M, Hasford J: Adverse drug reaction monitoring--digitoxin overdosage in the elderly. Int J Clin Pharmacol Ther. 2001 Aug;39(8):336-43. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11515708 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure. (en)
sameAs	Digitoxin Digitoxin
Title	Digitoxin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01396/identifier/chebi/28544 http://linked.opendata.cz/resource/drugbank/drug/DB01396/identifier/chemspider/389987 http://linked.opendata.cz/resource/drugbank/drug/DB01396/identifier/drugbank/DB01396 http://linked.opendata.cz/resource/drugbank/drug/DB01396/identifier/kegg-compound/C06955 http://linked.opendata.cz/resource/drugbank/drug/DB01396/identifier/kegg-drug/D00297 http://linked.opendata.cz/resource/drugbank/drug/DB01396/identifier/pharmgkb/PA449316 http://linked.opendata.cz/resource/drugbank/drug/DB01396/identifier/pubchem-compound/441207 http://linked.opendata.cz/resource/drugbank/drug/DB01396/identifier/pubchem-substance/46506035 http://linked.opendata.cz/resource/drugbank/drug/DB01396/identifier/wikipedia/Digitoxin
http://linked.open...mechanismOfAction	Digitoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Digitoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential. (en)
http://linked.open...drugbank/packager	Apotex inc
http://linked.open.../drugbank/synonym	Digitoxin (en) Digitoksin (en) Digitoxinum (en) Digitoxoside (en) Crystodigin (tn) (en)
http://linked.open...drugbank/toxicity	Digitoxin exhibits similar toxic effects to the more-commonly used digoxin, namely: anorexia, nausea, vomiting, diarrhoea, confusion, visual disturbances, and cardiac arrhythmias. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/92-02-00%2A
http://linked.open...k/foodInteraction	Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication. (en) Avoid avocado. (en) Avoid salt substitutes containing potassium. (en) Avoid bran and high fiber foods within 2 hours of taking this medication. (en) Limit garlic, ginger, gingko, and horse chestnut. (en) Avoid excess salt/sodium unless otherwise instructed by your physician. (en)
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	71-63-6 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Digitoxin powder
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