About: Hexobarbital

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A barbiturate that is effective as a hypnotic and sedative. [PubChem] (en)
http://linked.open...generalReferences	# Takenoshita R, Toki S: [New aspects of hexobarbital metabolism: stereoselective metabolism, new metabolic pathway via GSH conjugation, and 3-hydroxyhexobarbital dehydrogenases] Yakugaku Zasshi. 2004 Dec;124(12):857-71. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15577260 # Wahlstrom G: A study of the duration of acute tolerance induced with hexobarbital in male rats. Pharmacol Biochem Behav. 1998 Apr;59(4):945-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9586853 # Korkmaz S, Ljungblad E, Wahlstrom G: Interaction between flumazenil and the anesthetic effects of hexobarbital in the rat. Brain Res. 1995 Apr 10;676(2):371-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7614008 # Dall V, Orntoft U, Schmidt A, Nordholm L: Interaction of the competitive AMPA receptor antagonist NBQX with hexobarbital. Pharmacol Biochem Behav. 1993 Sep;46(1):73-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8255925 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. (en)
sameAs	Hexobarbital Hexobarbital
Title	Hexobarbital (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01355/identifier/chebi/5706 http://linked.opendata.cz/resource/drugbank/drug/DB01355/identifier/drugbank/DB01355 http://linked.opendata.cz/resource/drugbank/drug/DB01355/identifier/kegg-compound/C11723 http://linked.opendata.cz/resource/drugbank/drug/DB01355/identifier/kegg-drug/D01071 http://linked.opendata.cz/resource/drugbank/drug/DB01355/identifier/pharmgkb/PA449875 http://linked.opendata.cz/resource/drugbank/drug/DB01355/identifier/wikipedia/Hexobarbital
http://linked.open...mechanismOfAction	Hexobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. (en)
http://linked.open.../drugbank/synonym	Hexobarbital (en) Evipan (en) 5-(1-cyclohexen-1-yl)-1,5-dimethylbarbituric acid (en) Hexobarbitone (en) Methexenyl (en) Methylhexabital (en) 5-Cyclohex-1-enyl-1,5-dimethyl-pyrimidine-2,4,6-trione (en) 5-(1-Cyclohexen-1-yl)-1,5-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione (en)
http://linked.open...drugbank/toxicity	Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness or coma, shallow breathing, staggering, and in severe cases coma and death. (en)
http://linked.open...nk/proteinBinding	25% (en)
http://linked.open...ogy/drugbank/salt	(en)
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http://linked.open...l/drug/hasATCCode	Hexobarbital Hexobarbital
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	56-29-1 (en)
http://linked.open...drugbank/category	(en)
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