About: Galsulfase

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Galsufase is a variant form of the polymorphic human enzyme N-acetylgalactosamine 4-sulfatase of recombinant DNA origin. Galsulfase is a glycoprotein with a molecular weight of approximately 56 kD. The recombinant protein is comprised of 495 amino acids and contains six asparagine-linked glycosylation sites, four of which carry a bis mannose-6-phosphate manose7 oligosaccharide for specific cellular recognition. Post-translational modification of Cys53 produces the catalytic amino acid residue Ca-formylglycine, which is required for enzyme activity and is conserved in all members of the sulfatase enzyme family. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B6293-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Online.lexi.com.login.ezproxy.library.ualberta.ca,. 'University Of Alberta Libraries'. N.p., 2014. Web. 11 Nov. 2014. (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	9 (6 to 21) minutes during the first week of treatment, 26 (8 to 40) minutes by the 24th week. (en)
http://linked.open...ugbank/indication	For the treatment of adults and children with Mucopolysaccharidosis VI. (en)
sameAs	Galsulfase Galsulfase
Title	Galsulfase (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01279/identifier/drugbank/DB01279 http://linked.opendata.cz/resource/drugbank/drug/DB01279/identifier/pharmgkb/PA164746235 http://linked.opendata.cz/resource/drugbank/drug/DB01279/identifier/wikipedia/Galsulfase
http://linked.open...mechanismOfAction	Galsulfase supplies recombinant-engineered galsulfase, a normal variant form of the polymorphic human enzyme, N-acetylgalactosamine 4-sulfatase. It is a lysosomal hydrolase that catalyzes the cleavage of the sulfate ester from terminal N-acetylgalactosamine 4-sulfate residues of GAG chondroitin 4-sulfate and dermatan sulfate. Increased catabolism of GAG in turn reduces systemic dermatan sulfate accumulation, thereby reducing the primary symptoms of MPS VI. (en)
http://linked.open...drugbank/packager	Pfizer Inc.
http://linked.open.../drugbank/synonym	ARSB (en) Arylsufatase B (en)
http://linked.open...drugbank/toxicity	There is no experience with overdose of galsulfase. (en)
http://linked.open...umeOfDistribution	Week 1: 56-323 mL/kg and 59-2799 mL/kg by week 24 (en)
foaf:page	http://www.drugs.com/cdi/galsulfase.html http://www.rxlist.com/cgi/generic/naglazyme.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B6295-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B6294-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Galsulfase
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	552858-79-4 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Naglazyme 5 mg/5 ml vial

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