| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - A narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. [PubChem] (en)
|
| http://linked.open...gy/drugbank/group
| |
| http://linked.open...drugbank/halfLife
| |
| http://linked.open...ugbank/indication
| - For the treatment and management of opiate dependence. It is sometimes used to treat severe pain in terminal patients. (en)
|
| sameAs
| |
| Title
| - Levomethadyl Acetate (en)
|
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - Opiate receptors (Mu, Kappa, Delta) are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Levomethadyl acetate effectively opens calcium-dependent inwardly rectifying potassium channels (OP1 receptor agonist), resulting in hyperpolarization and reduced neuronal excitability. (en)
|
| http://linked.open.../drugbank/synonym
| - Levacetylmethadol (en)
- Orlaam (en)
- LAAM (en)
- Levomethadyl (en)
- (-)-alpha-Acetylmethadol (en)
- 1-alpha-Acetylmethadol (en)
- Levacetilmetadol (en)
- Levacetylmethadolum (en)
- Levo-alpha-acetylmethadol (en)
- Levo-methadyl acetate (en)
- Levo-α-acetylmethadol (en)
- Levomethadyl acetate (en)
- (1S,4S)-4-(dimethylamino)-1-Ethyl-2,2-diphenylpentyl acetate (en)
|
| http://linked.open...drugbank/toxicity
| - Signs of overdose include apnea, circulatory collapse, pulmonary edema, cardiac arrest, and death. (en)
|
| http://linked.open...nk/proteinBinding
| |
| http://linked.open...y/mesh/hasConcept
| |
| foaf:page
| |
| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
| |
| http://linked.open...noisotopic-Weight
| |
| http://linked.open...y/drugbank/SMILES
| |
| http://linked.open.../Water-Solubility
| |
| http://linked.open...ogy/drugbank/logP
| |
| http://linked.open...ogy/drugbank/logS
| |
| http://linked.open...l/drug/hasATCCode
| |
| http://linked.open...nd-Acceptor-Count
| |
| http://linked.open...-Bond-Donor-Count
| |
| http://linked.open...drugbank/InChIKey
| |
| http://linked.open...urface-Area--PSA-
| |
| http://linked.open...nk/Polarizability
| |
| http://linked.open...bank/Refractivity
| |
| http://linked.open...atable-Bond-Count
| |
| http://linked.open...ugbank/absorption
| - Levomethadyl acetate is rapidly absorbed from an oral solution. (en)
|
| http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
|
| http://linked.open...casRegistryNumber
| |
| http://linked.open...drugbank/category
| |
| http://linked.open...k/Bioavailability
| |
| http://linked.open...bank/Ghose-Filter
| |
| http://linked.open...nk/MDDR-Like-Rule
| |
| http://linked.open...k/Number-of-Rings
| |
| http://linked.open...siological-Charge
| |
| http://linked.open...bank/Rule-of-Five
| |
| http://linked.open...tional-IUPAC-Name
| |
| http://linked.open...-strongest-basic-
| |
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