About: Dexfenfluramine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. It was for some years in the mid-1990s approved by the United States Food and Drug Administration for the purposes of weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn. (en)
http://linked.open...gy/drugbank/group
  • approved (en)
  • illicit (en)
  • withdrawn (en)
http://linked.open...drugbank/halfLife
  • 17-20 hours (en)
http://linked.open...ugbank/indication
  • For the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet (en)
sameAs
Title
  • Dexfenfluramine (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Dexfenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin reuptake. The increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. (en)
http://linked.open.../drugbank/synonym
  • Dexfenfluramine (en)
  • (+)-fenfluramine (en)
  • (S)-fenfluramine (en)
  • Dextrofenfluramine (en)
  • Dexfenfluramina (en)
  • Dexfenfluraminum (en)
  • (S)-N-Ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine (en)
  • D-N-Ethyl-alpha-methyl-m-trifluoromethylphenethylamine (en)
http://linked.open...drugbank/toxicity
  • Symptoms of overdose include respiratory failure and cardiac arrest leading to death. (en)
http://linked.open...k/foodInteraction
  • Take with meals. (en)
http://linked.open...nk/proteinBinding
  • 36% (en)
http://linked.open...y/mesh/hasConcept
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • Well-absorbed from the gastrointestinal tract. (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 3239-44-9 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...-strongest-basic-
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