| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. [PubChem] (en)
|
| http://linked.open...y/drugbank/dosage
| |
| http://linked.open...generalReferences
| - # Ji D, Sui ZY, Ma YY, Luo F, Cui CL, Han JS: NMDA receptor in nucleus accumbens is implicated in morphine withdrawal in rats. Neurochem Res. 2004 Nov;29(11):2113-20. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15662845 (en)
|
| http://linked.open...gy/drugbank/group
| |
| http://linked.open...drugbank/halfLife
| |
| http://linked.open...ugbank/indication
| - Indicated for the treatment of Parkinson's disease. (en)
|
| sameAs
| |
| Title
| |
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - Orphenadrine binds and inhibits both histamine H1 receptors and NMDA receptors. It restores the motor disturbances induced by neuroleptics, in particular the hyperkinesia. The dopamine deficiency in the striatum increases the stimulating effects of the cholinergic system. This stimulation is counteracted by the anticholinergic effect of orphenadrine. It may have a relaxing effect on skeletal muscle spasms and it has a mood elevating effect. (en)
|
| http://linked.open...drugbank/packager
| |
| http://linked.open.../drugbank/synonym
| - ORPHENADRINE (en)
- N,N-Dimethyl-2-[(O-methyl-alpha-phenylbenzyl)oxy]ethylamine (en)
- 2-(phenyl-o-tolylmethoxy)ethyldimethylamine (en)
- 2-methyldiphenhydramine (en)
- Dimethyl-[2-(phenyl-O-tolyl-methoxy)-ethyl]-amine (en)
- N,N-Dimethyl-2-(alpha-2-tolylbenzoyloxy)ethylamine (en)
- N,N-Dimethyl-2-(phenyl(O-tolyl)methoxy)ethanamine (en)
- Orfenadrina (en)
- Orphenadrinum (en)
- Phenyl-O-tolylmethyl dimethyaminoethyl ether (en)
- beta-Dimethylaminoethyl 2-methylbenzhydryl ether (en)
- o-methyldiphenhydramine (en)
- o-monomethyldiphenhydramine (en)
- β-dimethylaminoethyl 2-methylbenzhydryl ether (en)
|
| http://linked.open...drugbank/toxicity
| - Oral, mouse LD<sub>50</sub> = 100 mg/kg; oral, rat LD<sub>50</sub> = 255 mg/kg (en)
|
| http://linked.open.../drug/hasAHFSCode
| |
| http://linked.open...k/foodInteraction
| - Take without regard to meals. Avoid alcohol. (en)
|
| http://linked.open.../drugbank/mixture
| |
| http://linked.open...nk/proteinBinding
| |
| http://linked.open...ogy/drugbank/salt
| |
| http://linked.open...y/mesh/hasConcept
| |
| foaf:page
| |
| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
| |
| http://linked.open...noisotopic-Weight
| |
| http://linked.open...y/drugbank/SMILES
| |
| http://linked.open.../Water-Solubility
| |
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