About: Arsenic trioxide

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Arsenic trioxide is a chemotheraputic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. Due to the toxic nature of arsenic, this drug carries significant health risks. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4DAF-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4DB0-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Lu J, Chew EH, Holmgren A: Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12288-93. Epub 2007 Jul 18. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17640917 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...ugbank/indication	For induction of remission and consolidation in patients with acute promyelocytic leukemia (APL), and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression (en)
sameAs	Arsenic trioxide Arsenic trioxide
Title	Arsenic trioxide (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01169/identifier/chemspider/452539 http://linked.opendata.cz/resource/drugbank/drug/DB01169/identifier/drugbank/DB01169 http://linked.opendata.cz/resource/drugbank/drug/DB01169/identifier/kegg-drug/D02106 http://linked.opendata.cz/resource/drugbank/drug/DB01169/identifier/national-drug-code-directory/63459-600-10 http://linked.opendata.cz/resource/drugbank/drug/DB01169/identifier/pharmgkb/PA448486 http://linked.opendata.cz/resource/drugbank/drug/DB01169/identifier/pubchem-compound/518740 http://linked.opendata.cz/resource/drugbank/drug/DB01169/identifier/pubchem-substance/46506448 http://linked.opendata.cz/resource/drugbank/drug/DB01169/identifier/wikipedia/Arsenic_trioxide
http://linked.open...mechanismOfAction	The mechanism of action of Arsenic Trioxide is not completely understood. Arsenic trioxide causes morphological changes and DNA fragmentation characteristic of apoptosis in NB4 human promyelocytic leukemia cells <i>in vitro</i>. Arsenic trioxide also causes damage or degradation of the fusion protein PML/RAR-alpha. It is suspected that arsenic trioxide induces cancer cells to undergo apoptosis. (en)
http://linked.open...drugbank/packager	Akorn Inc. Inwood laboratories inc sub forest laboratories inc Ben venue laboratories inc CP Pharmaceuticals Ltd. Barr laboratories inc Cadista pharmaceuticals inc
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/6723351
http://linked.open...outeOfElimination	Trivalent arsenic is mostly methylated in humans and excreted in urine. (en)
http://linked.open.../drugbank/synonym	Arseni Trioxydum (en) Arsenic Oxidearsenous Trioxide (en) Arsenious Acid (en) Arsenious Acid Anhydride (en) Arsenious Trioxide (en) Arsentrioxide (en) Acide Arsenieux (en) Anhydride Arsenieux (en) Arsenic Blanc (en) Arsenigen Saure (en) Oxyde Arsenieux (en)
http://linked.open...drugbank/toxicity	Symptoms of overdose include convulsions, muscle weakness and confusion. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/92-02-00%2A
http://linked.open...nk/proteinBinding	75% bound (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0049263
foaf:page	http://www.drugs.com/cdi/arsenic.html http://www.rxlist.com/cgi/generic2/arsenic.htm
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	1327-53-3 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Arsenic trioxide powder Trisenox 10 mg/10 ml ampule
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