About: Benzylpenicillin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type
http://linked.open...gbank/description
  • Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as <i>Streptococcus pneumoniae</i>, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (<i>S. agalactiae</i>), <i>S. viridans</i>, and <i>Enterococcus faecalis</i>. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as <i>Bacillus anthracis</i>, <i>Corynebacterium diphtheriae</i>, and <i>Erysipelothrix rhusiopathiae</i>. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by <i>Neisseria meningitidis</i> and <i>Pasteurella</i>. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions. (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # Eagle H, Newman E, Musselman AD, Robinson M, Birmingham M: THE RENAL CLEARANCE OF PENICILLINS F, G, K, AND X IN RABBITS AND MAN. J Clin Invest. 1947 Sep;26(5):903-18. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16695494 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • In adults with normal renal function is reportedly 0.4–0.9 hours (en)
http://linked.open...ugbank/indication
  • For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required such as in the treatment of septicemia, meningitis, pericarditis, endocarditis and severe pneumonia. (en)
sameAs
Title
  • Benzylpenicillin (en)
adms:identifier
http://linked.open...mechanismOfAction
  • By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, penicillin G inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that penicillin G interferes with an autolysin inhibitor. (en)
http://linked.open...drugbank/packager
http://linked.open...outeOfElimination
  • Penicillin G is eliminated by the kidneys. Nonrenal clearance includes hepatic metabolism and, to a lesser extent, biliary excretion. (en)
http://linked.open.../drugbank/synonym
  • Benzylpenicillin (en)
  • Penicillin G (en)
  • 6-(2-phenylacetamido)penicillanic acid (en)
  • Bencilpenicilina (en)
  • Benzylpenicilline (en)
  • Benzylpenicillinic acid (en)
  • Benzylpenicillinum (en)
  • Free penicillin ii (en)
  • PCG (en)
  • PG (en)
  • (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (en)
http://linked.open...drugbank/toxicity
  • Oral LD<sub>50</sub> in rat is 8900 mk/kg. Neurological adverse reactions, including convulsions, may occur with the attainment of high CSF levels of beta-lactams. Neutropenia can occur if high doses are administered consistently for over 2 weeks. (en)
http://linked.open...umeOfDistribution
  • 0.53–0.67 L/kg in adults with normal renal function (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...nk/proteinBinding
  • Bind to serum proteins (45-68%), mainly albumin. (en)
http://linked.open...ogy/drugbank/salt
  • (en)
http://linked.open...ynthesisReference
  • Gunter Schumacher, Peter Buckel, "Plasmids for the increased production of penicillin G amidase." U.S. Patent US5053335, issued May, 1984. (en)
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
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http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
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http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • Rapidly absorbed following both intramuscular and subcutaneous injection. Initial blood levels following parenteral administration are high but transient. Oral absorption in fasting, healthy humans is only about 15-30% as it is very susceptible to acid-catalyzed hydrolysis. (en)
http://linked.open.../affectedOrganism
  • Enteric bacteria and other eubacteria (en)
  • Streptococcus pyogenes (en)
  • Staphylococcus aureus (en)
  • Staphylococcus epidermidis (en)
http://linked.open...casRegistryNumber
  • 61-33-6 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...rugbank/clearance
  • 560ml/min in healthy humans (en)
http://linked.open...gbank/containedIn
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
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