| Attributes | Values |
|---|
| rdf:type
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| http://linked.open...gbank/description
| - Phylloquinone is often called vitamin K1. It is a fat-soluble vitamin that is stable to air and moisture but decomposes in sunlight. It is found naturally in a wide variety of green plants. Phylloquinone is also an antidote for coumatetralyl. Vitamin K is needed for the posttranslational modification of certain proteins, mostly required for blood coagulation. (en)
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| http://linked.open...y/drugbank/dosage
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| http://linked.open...gy/drugbank/group
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| http://linked.open...ugbank/indication
| - For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia. (en)
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| http://linked.open...bank/manufacturer
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| sameAs
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| Title
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| adms:identifier
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| http://linked.open...mechanismOfAction
| - Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttranslational gamma-carboxylation of glutamic acid residues in inactive hepatic precursors of coagulation factors II (prothrombin), VII, IX and X. Gamma-carboxylation converts these inactive precursors into active coagulation factors which are secreted by hepatocytes into the blood. Supplementing with Phylloquinone results in a relief of vitamin K deficiency symptoms which include easy bruisability, epistaxis, gastrointestinal bleeding, menorrhagia and hematuria. (en)
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| http://linked.open...drugbank/packager
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| http://linked.open...outeOfElimination
| - Almost no free unmetabolized vitamin K appears in bile or urine. (en)
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| http://linked.open.../drugbank/synonym
| - Phytomenadione (en)
- Phytonadione (en)
- 3-Phytylmenadione (en)
- Phyllochinon (en)
- Phylloquinone (en)
- Phytylmenadione (en)
- Vitamin K1 (en)
- alpha-Phylloquinone (en)
- 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione (en)
- 2-Methyl-3-phytyl-1,4-naphthochinon (en)
- 2-Methyl-3-phytyl-1,4-naphthoquinone (en)
- Fitomenadiona (en)
- Phyllochinonum (en)
- Phythyl-menadion (en)
- Phytomenadionum (en)
- Phytonadionum (en)
- trans-Phylloquinone (en)
- 2-Methyl-3-[(2e)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone (en)
- α-phylloquinone (en)
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| http://linked.open...drugbank/toxicity
| - The intravenous LD<sub>50</sub> of phylloquinone in the mouse is 41.5 and 52 mL/kg for the 0.2% and 1% concentrations, respectively. (en)
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| http://linked.open...ynthesisReference
| - Manfred Dorner, "Method of making vitamin K1." U.S. Patent US5744624, issued June, 1964. (en)
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| http://linked.open...y/mesh/hasConcept
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| foaf:page
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| http://linked.open...ugbank/IUPAC-Name
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| http://linked.open...gy/drugbank/InChI
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| http://linked.open...Molecular-Formula
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| http://linked.open.../Molecular-Weight
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| http://linked.open...noisotopic-Weight
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| http://linked.open...y/drugbank/SMILES
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| http://linked.open.../Water-Solubility
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| http://linked.open...ogy/drugbank/logP
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| http://linked.open...ogy/drugbank/logS
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| http://linked.open...l/drug/hasATCCode
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| http://linked.open...nd-Acceptor-Count
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| http://linked.open...-Bond-Donor-Count
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| http://linked.open...drugbank/InChIKey
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| http://linked.open...urface-Area--PSA-
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| http://linked.open...nk/Polarizability
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| http://linked.open...bank/Refractivity
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| http://linked.open...atable-Bond-Count
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| http://linked.open...ugbank/absorption
| - Oral phylloquinone is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phylloquinone is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues. (en)
|
| http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
|
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