About: Hydrochlorothiazide

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4DE1-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4DE2-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4DE3-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4DE4-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4DE5-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4DE6-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	5.6 and 14.8 hours (en)
http://linked.open...ugbank/indication	For the treatment of high blood pressure and management of edema. (en)
http://linked.open...bank/manufacturer	Dept Health Central Pharmacy Direct Dispensing Inc. Dispensing Solutions Diversified Healthcare Services Inc. Emcure Pharmaceuticals Ltd. Heartland Repack Services LLC Ivax Pharmaceuticals Lake Erie Medical and Surgical Supply Abc holding corp Actavis elizabeth llc Alra laboratories inc Murfreesboro Pharmaceutical Nursing Supply Barr laboratories inc Caraco pharmaceutical laboratories ltd Dava pharmaceuticals inc Elkins sinn div ah robins co inc Excellium pharmaceutical inc Heather drug co inc Heritage pharmaceuticals inc Akorn Inc. Inwood laboratories inc sub forest laboratories inc Ben venue laboratories inc CP Pharmaceuticals Ltd. Barr laboratories inc Cadista pharmaceuticals inc Pfizer Inc. Everylife Excellium pharmaceutical inc Halsey drug co inc APP Pharmaceuticals Hospira Inc. Ivax pharmaceuticals inc sub teva pharmaceuticals usa Lannett co inc Eli lilly and co Halsey drug co inc Merck and co inc Abbott laboratories pharmaceutical products div Apotex inc Aurobindo pharma ltd Pharmaceutical Utilization Management Program VA Inc. Corepharma LLC Ivax pharmaceuticals inc sub teva pharmaceuticals usa
sameAs	Hydrochlorothiazide Hydrochlorothiazide
Title	Hydrochlorothiazide (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00999/identifier/bindingdb/13076 http://linked.opendata.cz/resource/drugbank/drug/DB00999/identifier/drugbank/DB00999 http://linked.opendata.cz/resource/drugbank/drug/DB00999/identifier/kegg-drug/D00340 http://linked.opendata.cz/resource/drugbank/drug/DB00999/identifier/national-drug-code-directory/0378-3603-01 http://linked.opendata.cz/resource/drugbank/drug/DB00999/identifier/pharmgkb/PA449899 http://linked.opendata.cz/resource/drugbank/drug/DB00999/identifier/wikipedia/Hydrochlorothiazide
http://linked.open...mechanismOfAction	Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption. Normally, the sodium-chloride symporter transports sodium and chloride from the lumen into the epithelial cell lining the distal convoluted tubule. The energy for this is provided by a sodium gradient established by sodium-potassium ATPases on the basolateral membrane. Once sodium has entered the cell, it is transported out into the basolateral interstitium via the sodium-potassium ATPase, causing an increase in the osmolarity of the interstitium, thereby establishing an osmotic gradient for water reabsorption. By blocking the sodium-chloride symporter, hydrochlorothiazide effectively reduces the osmotic gradient and water reabsorption throughout the nephron. (en)
http://linked.open...drugbank/packager	Able laboratories inc Accucaps Industries Ltd. Advanced Pharmaceutical Services Inc. Ajanta Pharma Ltd. Amend Amerisource Health Services Corp. Apace Packaging Apotheca Inc. APP Pharmaceuticals A-S Medication Solutions LLC Avkare Incorporated Avpak Pfizer Inc. Pharmaceutical Utilization Management Program VA Inc. Bryant Ranch Prepack Cadista Pharmaceuticals Inc. Cardinal Health Pharmaceutical Utilization Management Program VA Inc. Chemins Co. Inc. Comprehensive Consultant Services Inc. Consolidated Midland Corp. Contract Pharm Coupler Enterprises Inc. CVS Pharmacy Cypress Pharmaceutical Inc. DAVA Pharmaceuticals Deca Pharmaceuticals LLC Dept Health Central Pharmacy Pfizer Inc. Direct Dispensing Inc. Dispensing Solutions Pharmaceutical Utilization Management Program VA Inc. Sandoz Excellium Pharmaceutical Inc. Heartland Repack Services LLC Ivax Pharmaceuticals JLM Pharmatech

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