| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - An immunosuppressive antimetabolite pro-drug. It is an imidazolyl derivative of 6-mercaptopurine and many of its biological effects are similar to those of the parent compound. Azathioprine is converted into 6-mercaptopurine in the body where it blocks purine metabolism and DNA synthesis. (en)
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| http://linked.open...y/drugbank/dosage
| |
| http://linked.open...generalReferences
| - # Konstantopoulou M, Belgi A, Griffiths KD, Seale JR, Macfarlane AW: Azathioprine-induced pancytopenia in a patient with pompholyx and deficiency of erythrocyte thiopurine methyltransferase. BMJ. 2005 Feb 12;330(7487):350-1. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15705694 # Woodroffe R, Yao GL, Meads C, Bayliss S, Ready A, Raftery J, Taylor RS: Clinical and cost-effectiveness of newer immunosuppressive regimens in renal transplantation: a systematic review and modelling study. Health Technol Assess. 2005 May;9(21):1-179, iii-iv. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15899149 # Gombar VK, Enslein K, Blake BW: Carcinogenicity of azathioprine: an S-AR investigation. Mutat Res. 1993 May;302(1):7-12. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7683109 (en)
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| http://linked.open...gy/drugbank/group
| |
| http://linked.open...ugbank/indication
| - For use in rheumatoid arthritis, preventing renal transplant rejection, Crohn's disease, and colitis. (en)
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| http://linked.open...bank/manufacturer
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| sameAs
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| Title
| |
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - Azathioprine antagonizes purine metabolism and may inhibit synthesis of DNA, RNA, and proteins. It may also interfere with cellular metabolism and inhibit mitosis. Its mechanism of action is likely due to incorporation of thiopurine analogues into the DNA structure, causing chain termination and cytotoxicity. (en)
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| http://linked.open...drugbank/packager
| |
| http://linked.open...outeOfElimination
| - Both compounds are rapidly eliminated from blood and are oxidized or methylated in erythrocytes and liver; no azathioprine or mercaptopurine is detectable in urine after 8 hours. (en)
|
| http://linked.open.../drugbank/synonym
| - Imuran (tn) (en)
- 6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine (en)
- 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine (en)
|
| http://linked.open...drugbank/toxicity
| - The oral LD<sub>50</sub> for single doses of azathioprine in mice and rats are 2500 mg/kg and 400 mg/kg, respectively. Very large doses of this antimetabolite may lead to marrow hypoplasia, bleeding, infection, and death. (en)
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| http://linked.open.../drug/hasAHFSCode
| |
| http://linked.open...k/foodInteraction
| - Take with food to reduce irritation. (en)
|
| http://linked.open...nk/proteinBinding
| - Azathioprine and the metabolite mercaptopurine are moderately bound to serum proteins (30%). (en)
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| http://linked.open...ogy/drugbank/salt
| |
| http://linked.open...y/mesh/hasConcept
| |
| foaf:page
| |
| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
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| http://linked.open...noisotopic-Weight
| |
| http://linked.open...y/drugbank/SMILES
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| http://linked.open.../Water-Solubility
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| http://linked.open...ogy/drugbank/logP
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| http://linked.open...ogy/drugbank/logS
| |
| http://linked.open...logy/drugbank/pKa
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| http://linked.open...l/drug/hasATCCode
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| http://linked.open...nd-Acceptor-Count
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| http://linked.open...-Bond-Donor-Count
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| http://linked.open...drugbank/InChIKey
| |
| http://linked.open...urface-Area--PSA-
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| http://linked.open...nk/Polarizability
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| http://linked.open...bank/Refractivity
| |
| http://linked.open...atable-Bond-Count
| |
| http://linked.open...ugbank/absorption
| - Well absorbed following oral administration. (en)
|
| http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
|
| http://linked.open...casRegistryNumber
| |
| http://linked.open...drugbank/category
| |
| http://linked.open...gbank/containedIn
| |
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