About: Dipyridamole

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B475E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B475F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4760-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4761-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4762-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4763-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4764-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4765-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4769-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4767-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4768-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4766-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Diener HC, Cunha L, Forbes C, Sivenius J, Smets P, Lowenthal A: European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci. 1996 Nov;143(1-2):1-13. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8981292 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	40 minutes (en)
http://linked.open...ugbank/indication	For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina. (en)
http://linked.open...bank/manufacturer	21st Century Healthcare Inc. App pharmaceuticals llc Baxter healthcare corp anesthesia and critical care Prepak Systems Inc. Claris lifesciences ltd Hospira inc Apotheca Inc. APP Pharmaceuticals A-S Medication Solutions LLC Barr laboratories inc C.O. Truxton Inc. Sandoz Carlisle Laboratories Inc. Central Texas Community Health Centers Claris Lifesciences Inc. Amend Comptoir Francaise De Productores Boehringer Ingelheim Pharmaceuticals, Inc
sameAs	Dipyridamole Dipyridamole
Title	Dipyridamole (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00975/identifier/bindingdb/23620 http://linked.opendata.cz/resource/drugbank/drug/DB00975/identifier/chebi/4653 http://linked.opendata.cz/resource/drugbank/drug/DB00975/identifier/chemspider/2997 http://linked.opendata.cz/resource/drugbank/drug/DB00975/identifier/drugbank/DB00975 http://linked.opendata.cz/resource/drugbank/drug/DB00975/identifier/kegg-drug/D00302 http://linked.opendata.cz/resource/drugbank/drug/DB00975/identifier/national-drug-code-directory/55390-555-10 http://linked.opendata.cz/resource/drugbank/drug/DB00975/identifier/pharmgkb/PA449367 http://linked.opendata.cz/resource/drugbank/drug/DB00975/identifier/pubchem-compound/3108 http://linked.opendata.cz/resource/drugbank/drug/DB00975/identifier/pubchem-substance/46506292 http://linked.opendata.cz/resource/drugbank/drug/DB00975/identifier/wikipedia/Dipyridamole
http://linked.open...mechanismOfAction	Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation. (en)
http://linked.open...drugbank/packager	Magno-Humphries Laboratories Ivax Pharmaceuticals Kaiser Foundation Hospital Lake Erie Medical and Surgical Supply Liberty Pharmaceuticals Luitpold Pharmaceuticals Inc. Macnary Ltd. Major Pharmaceuticals Mckesson Corp. Medvantx Inc. Pharmaceutical Utilization Management Program VA Inc. Murfreesboro Pharmaceutical Nursing Supply Mylan Neighborcare Repackaging Inc. Neuman Distributors Inc. Norwich Pharmaceuticals Inc. Nucare Pharmaceuticals Inc. Ohm Laboratories Inc. Palmetto Pharmaceuticals Inc. Patheon Inc. PCA LLC PD-Rx Pharmaceuticals Inc. Pharmaceutical Utilization Management Program VA Inc. Pharmedix Physicians Total Care Inc. Barr Pharmaceuticals General Injectables and Vaccines Inc. Barr laboratories inc Group Health Cooperative H and H Laboratories Eli lilly and co Amerisource Health Services Corp. Apotex Inc. APP Pharmaceuticals Avkare Incorporated Barr Pharmaceuticals Barr laboratories inc Bedford Labs Ivax pharmaceuticals inc sub teva pharmaceuticals usa Boehringer Ingelheim Ltd. Cadila Healthcare Ltd. Cardinal Health Direct Dispensing Inc. Dispensing Solutions Hospira Inc. Impax Laboratories Inc. Ipca Laboratories Ltd.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/6015577
http://linked.open...outeOfElimination	Dipyridamole is metabolized in the liver to the glucuronic acid conjugate and excreted with the bile. (en)
http://linked.open.../drugbank/synonym	Cardoxin (en)

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